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Mobile application for 3D reconstruction
Krátký, Martin ; Janáková, Ilona (referee) ; Richter, Miloslav (advisor)
The aim of this master thesis is to create mobile application for spatial reconstruction. Thesis describes image processing methods suitable for solving this problem. Available platforms for creating mobile application are described. The parameters of the measured scenes are defined. A mobile application containing the described methods is created. The application is tested by reconstruction of objects in different conditions.
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3D model
Krátký, Martin ; Klečka, Jan (referee) ; Richter, Miloslav (advisor)
The aim of this bachelor thesis is to create a spatial model from images capturing an object illuminated by a laser pattern. The thesis presents possible solutions to the problem using methods of active triangulation and stereoscopy. Methods are designed for laboratory and outdoor measurements. The requirements for the measuring workplace are defined and then the implemented workplace is presented. Each of the designed methods is tested by scanning a series of objects.
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PLC simulation using TwinCat tool
Krátký, Martin ; Uher, Václav (referee) ; Mašek, Jan (advisor)
Bachelor project is about options in TwinCat 2 for programming the programmable logic controller (PLC). As part of the work will be described the principle of the PLC and PLC uses nowadays. The principe of developing tool TwinCAT will be described and an overview of the programming languages that standard IEC / EN 61131-3. The main contribution of this work is to create a program description in TwinCAT development tool in version 2. The main result will be a simulation of robotic arm created in TwinCAT version 3 and for this simulation will also be created graphical interface in Visual Studio in language C#.
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Chassis of tractors
Krátký, Martin ; Vopařil, Jan (referee) ; Kaplan, Zdeněk (advisor)
This bachelor thesis deals with the currently used chassis of wheeled and tracked tractors. In the first part is an overview and a short description of individual components. The second and third parts are focused on steering of wheeled and tracked tractors. There are in detail described different types of steering and is given a principle of operation. Most of space is devoted to hydrostatic steering which is the most widespread. In the end is summarized a present situation in designing of tractor chassis. There are mentioned used solutions and are described new modern systems and is estimated a supposed trend of development.
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Analysis of technical-economic parameters of the tractor kits in transport
Krátký, Martin ; Slimařík, Dušan (referee) ; Bauer, František (advisor)
This thesis deals with the use of the tractor in agricultural transport. The first part describes the current status in construction of tractor engines, transmissions and chassis that are used in tractors suitable for transport. The theoretical section includes an overview of the legislative requirements that must be followed for the tractor kits in transport on the road. The main objective of this thesis was to evaluate a measuring of fuel consumption and efficiency of the tractor JCB Fastrac 185-65 with two flatbed trailers. For this purpose was created the methodics off terrain measurement, which were carried out for different operation modes of the engine. The results were tabular and graphical processing including determining the accuracy of the method by calculating the relative error of measurement. For comparison a theoretical calculation of the consumed fuel was made. The aim of the measurements was to demonstrate fuel-saving during operation engine in the economic field and get an overview about fuel consumption and efficiency kits.
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Design of the Tractor's front axle drive
Podhora, David ; Krátký, Martin (referee) ; Prokop, Aleš (advisor)
This master’s thesis is deal with the design of the tractor’s front axle drive to enlarge its braking efficiency of the standing tractor fixed by the parking brake. In the first two chapters, the basic information related to the above stated issue is being summarized. Next, procedure of creating the design including the fundamental calculation proposal is being described. In the last chapter, the strain-stress analysis of the selected partial sections of the design is being presented. The final design is supported with the drawing documentation that is being part of this master’s thesis, too.
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Synthesis and evaluation of potential biologically active rhodanine derivatives and analogues
Šimková, Adéla ; Krátký, Martin (advisor) ; Matouš, Petr (referee)
The topic of this thesis is the synthesis of rhodanine derivatives and evaluation of their biological activity, particularly as potential cholinesterases inhibitors. This group of compounds is important for treatment of many diseases, e.g., Alzheimer's disease or myasthenia gravis. All synthetized compounds are based on structure of rhodanine (2-thioxothiazolidine- 4-one), which is an important heterocyclic compound with a wide spectrum of biological properties. Its structure can be modified in many ways, which can be used in the development of new drugs. Its derivatives have been shown to have, for example, anti-inflammatory, anticancer, antibacterial and antifungal activities, as well as inhibitory activity against several enzymes, e.g., cholinesterases. Seventeen compounds were synthesized in sufficient amount for characterisation and assessment of biological activity (7-93 %). Most of them are amides based on the structure of 2-thioxothiazolidine-4-one and thiazolidine-2,4-dione, that were prepared by carbodiimide- mediated coupling, other derivatives are based on the structure of 2-thioxothiazolidine-4-one and from 2,4-dioxothiazolidine-3-acetic acid. These compounds were prepared by Knoevenagel condensation in glacial acetic acid. All compounds were tested for their inhibitory activity...
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Synthesis and evaluation of potential antimicrobial drugs
Pflégr, Václav ; Krátký, Martin (advisor) ; Doležal, Martin (referee) ; Brulíková, Lucie (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Training Workplace Department of Organic and Bioorganic Chemistry Doctoral Degree Program Bioorganic Chemistry Candidate: Mgr. Václav Pflégr Supervisor: doc. PharmDr. Mgr. Martin Krátký, Ph.D. Title of Doctoral Thesis: Synthesis and evaluation of potential antimicrobial drugs The dissertation thesis reports some results achieved within the framework of a doctoral project dealing with the synthesis and evaluation of potential antimicrobial drugs. The main goal was to obtain new derivatives of isoniazid and its analogues acting against Mycobacterium tuberculosis and non-tuberculous mycobacteria, optimally including resistant strains. A partial aim was the preparation of peptide carriers for antituberculosis drugs, which, in addition to the development of new molecules, is another promising direction for the development of new therapeutic strategies against tuberculosis. The theoretical part of the dissertation overviews the issue of tuberculosis. The aetiology of the disease, the morphology of the cell wall of mycobacteria and selected epidemiological data are presented there. The treatment and characteristics of clinically used drugs are described in detail, this chapter is followed by a brief research review of promising clinically evaluated...
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Synthesis of substituted oxadiazoles with potential antimycobacterial activity
Mészárosová, Daniela ; Karabanovich, Galina (advisor) ; Krátký, Martin (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Author: Daniela Mészárosová Supervisor: Ing. Galina Karabanovich, Ph.D. Title of Diploma Thesis: Synthesis of substituted oxadiazoles with potential antimycobacterial activity Tuberculosis is an infectious disease caused by mycobacteria Mycobacterium tuberculosis, which is one of the top ten causes of death worldwide. According to the World Health Organization, 10.4 million new cases were reported in 2016 and 1.7 million people died of this disease (including 0.4 million people with HIV). Treatment of tuberculosis caused by drug-susceptible strains of M. tuberculosis is very successful, with up to 82% of patients cured. However, a major problem is the therapy of patients with drug resistant strains of M. tuberculosis. Multidrug-resistant tuberculosis (MDR-TB) is a TB that cannot be cured by isoniazid (INH) or rifampicin (RIF), the two most effective first-line antituberculotics. In this case, TB is treated with second-line antituberculotics, which should be administered for up to two years. However, according to statistics, only 32.2% of patients with MDR-TB are successfully cured in the European Union. Therefore, it is important to look for and develop new drugs that act on MDR-TB and can help...
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