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Proměny veřejného parku v čase
Koutná, Iveta
The diploma thesis with the name Changes of public park during the time deals with study of changes of public parks in city organism. The main topic is focused on historical and current role of public parks, which are summarized in short literrature review. Selected reference examples represen succeful implementaion of changes of public parks which are responding to current requirement. The findings are formulated for own approaches to proposal part of model object. For architectural study was selected park on the square Náměstí 28. října in Brno. These architectural study is supported by graphical illustrations. The concept of proposal is preceded by an extensive analytical and historical research.
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Nuclear topography of genes, centromeric heterochromatin and chromosomal domains in human granulocytes
Bártová, Eva ; Kozubek, Stanislav ; Jirsová, Pavla ; Kozubek, Michal ; Lukášová, Emilie ; Skalníková, M. ; Cafourková, Alena ; Koutná, Irena ; Paseková, R.
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Changes in the chromatin structure during granulocytic differentiation
Bártová, Eva ; Jirsová, Pavla ; Skalníková, M. ; Kozubek, Stanislav ; Kozubek, Michal ; Lukášová, Emilie ; Cafourková, Alena ; Koutná, I. ; Paseková, R. ; Matula, Pa. ; Matula, Pe.
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Klastrování genů s podobným regulačním mechanismem během monocytární a garanulocytární diferenciace buněk HL-60
Koutná, I. ; Faltýsková, E. ; Krontorád, P. ; Svoboda, Z. ; Pavlík, T. ; Bártová, Eva ; Kozubek, Michal ; Kozubek, Stanislav
In the present study, a high density-microarrays of human cDNA containing 19,000 genetic elements were used to search for differences in gene expression of human promyelic leukaemia cell line HL-60 during monocyte (MD) and granulocyte differentiation (GD). For differentiation to monocytes (granulocytes), the TPA, 12-O-tetradecanoylphorbol-D-acetate (DMSO) were used, respectively. A total number of 4625 (4760) genes were found to be regulated during MD (GD). The genes have been divided into groups according to their kinetics of regulation (R-groups). The genes of the same group are not distributed randomly throughout the genome but form clusters on chromosomes (R-clusters). Thus, functionally interconnected genes are frequently localized near to each other on the DNA molecule.
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