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The effect of melatonin for sleep regulation in humans with autism
Spišská, Veronika ; Bendová, Zdeňka (advisor) ; Kopřivová, Jana (referee)
Autism is, mainly in children, accompanied by a variety of sleep and circadian disorders. These disorders may be partly caused by problems in the synthesis of melatonin. This work is interested in sleep and circadian problems of children with autism and their possible treatment with exogenous melatonin. The paper presents the symptoms of autism and its causes, the basic principles of circadian system, the regulation of melatonin synthesis and the characteristics of sleep. The last chapter describes the changes in melatonin synthesis and disturbances in the production of other hormones (serotonin, cortisol). Sleep and circadian disorders in autistic individuals and their impact on other symptoms of autism such as communication and socialization are also listed in the last chapter. There are also cases of the treatment of sleep disorders in autistic children with melatonin reported. Treatment with melatonin improves sleep disorders and has almost no side effects. Key words: autism, circadian system, melatonin, sleep
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Animal models of obsessive-compulsive disorder
Radostová, Dominika ; Stuchlík, Aleš (advisor) ; Kopřivová, Jana (referee)
Obsessive compulsive disorder (OCD) is a widespread chronic psychiatric disorder, presenting itself with a wide range of symptoms. The heterogenity of OCD manifestations hinders the resarch and the interpretation of acquired results. Clinical studies are complemented by new insights collected from studies of animal models of OCD, which are nowdays integral to the resarch of OCD. During the course of the resarch many genetic, behavioral and pharmacologic animal models were developed. Number of works were not worked on further, however some models had been studied for a long time. Evaluation of individual models is dependant on many factors, and therefore the degree of validity and suitability for resarch differs between them. Powered by TCPDF (www.tcpdf.org)
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Headline - comparison of headlines in tabloid and serious press and their internet version
Kopřivová, Jana ; Chejnová, Pavla (advisor) ; Holanová, Radka (referee)
The aim of this study was trace the general tendence in the produce of headlines in the tabloid and serious press and their internet versions. The basis for this work was a sample of twelve newspaper headlines that came out in January and February 2013. There were drawn following conclusions on the basis of stylistic and pragmatic analysis and comparison of these titles. Analyzed subtitles are different designs and used language tools. The tabloid media is trying to attract potential readers, especially graphic design titles, while serious media put more accent on the content of the title message. The tabloid headlines have characteristic color caps and overhang headling to other cell components. Headlines of serious media are printed in black and stands on the site separately. One of the differences between tabloid headlines and serious media is their length - tabloid usually decide for shortes ones than the serious media. Basis subtitles should form a neutral literary language, yet there are presented present colloquial expressions in the headlines of tabloids and media. Tabloid headlines include expressive sign unlike the serious media headlines. Statements in the headlines are assertive and have interrogative and directive use. The tabloid media uses interrogative function in headlins more than the...
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Functional-imaging and electrophysiological correlates of obsessive-compulsive disorder and their potential use in neurofeedback intervention
Kopřivová, Jana ; Horáček, Jiří (advisor) ; Papežová, Hana (referee) ; Stuchlík, Aleš (referee)
Background: Obsessive-compulsive disorder (OCD) is a common mental disorder that may seriously affect quality of life and even the ability to work. Despite advanced medical care there are still patients who do not respond or do not respond sufficiently to treatment. Recently proposed treatment strategies such as deep brain stimulation or repetitive transcranial magnetic stimulation have targeted several levels of fronto-striatal circuits which dysfunction underlies OCD pathophysiology. Likewise, neurofeedback (NFB) could target dysfunctional fronto-striatal networks by providing almost real- time feedback about their activity. As the success of these methods critically depends on good knowledge of dysfunctional loops in OCD, a more detailed investigation of neurobiological basis of this disorder is highly needed. Aims: The aim of the first part of this dissertation was to provide an overview of the current literature related to OCD and NFB. The second section of the thesis is based on five original studies of the author that were conceived to 1) explore anatomical correlate of OCD in our patients, 2) to verify its functional relevance and specificity in electroencephalographic (EEG) studies, and 3) to test the utility of the findings in NFB treatment of OCD. Methods: In our studies we included...
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Strategic Analysis of an Enterprise
Kopřivová, Jana ; Dvořák, Jiří (advisor) ; Elexhauserová, Lenka (referee)
First part of my work deals with strategy, strategic management, strategic analysis and describes individual analysis. The practical part begins with the company presentation. In the practical part were used analysis such as PEST analysis, "4C" analysis , Porter's 5F model, analysis of enterprise resources or financial analysis. At the end of my work are shown conclusions and recommendations for company.
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