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Hemarthrosis in hemophilia: new treatment methods and the effect of hemarthroses repetition on joints sensitivity
Teyssler, Petr ; Bobek, Vladimír (advisor) ; Jahoda, David (referee) ; Komrska, Vladimír (referee)
Intraarticular bleeding is a complication, that concerns almost every person with haemophilia. The number and heaviness of them depends on the grade of illness and on presence of inhibitor. Presence of blood inside joint cavity leads to destruction of joint cartilage and haemophilic artropathy occures. Consequent events are as follows: bleeding - synovial irritation - re-bleeding - chronic haemophilic synovitis - haemophilic artropathy. There are four main targets of this work: 1. to summarize the possibilities of treatment of chronic haemophilic artropathy with radionuclides and to rise indication criteria for that kind of treatment, 2. to evaluace retrospectively long term efficacy od radiation synovectomy with corelation to other methods of treatment, 3. to find out, if platelet-rich-plasma therapy is effective in chronic haemophilic artropathy and 4. to find out, what is the effect of repeated intraarticular bleedings on joints sensitivity. 4 hypothesis are pronounced and methodology of their confirmation or disprove is described. There are results presented of prospective study of radiation synovectomy including recommendation of treatment indication. Further, this method is compared to other ones, from the point of view of the long term efficacy in retrospective study. Beneficial effect of...
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Hemarthrosis in hemophilia: new treatment methods and the effect of hemarthroses repetition on joints sensitivity
Teyssler, Petr ; Bobek, Vladimír (advisor) ; Jahoda, David (referee) ; Komrska, Vladimír (referee)
Intraarticular bleeding is a complication, that concerns almost every person with haemophilia. The number and heaviness of them depends on the grade of illness and on presence of inhibitor. Presence of blood inside joint cavity leads to destruction of joint cartilage and haemophilic artropathy occures. Consequent events are as follows: bleeding - synovial irritation - re-bleeding - chronic haemophilic synovitis - haemophilic artropathy. There are four main targets of this work: 1. to summarize the possibilities of treatment of chronic haemophilic artropathy with radionuclides and to rise indication criteria for that kind of treatment, 2. to evaluace retrospectively long term efficacy od radiation synovectomy with corelation to other methods of treatment, 3. to find out, if platelet-rich-plasma therapy is effective in chronic haemophilic artropathy and 4. to find out, what is the effect of repeated intraarticular bleedings on joints sensitivity. 4 hypothesis are pronounced and methodology of their confirmation or disprove is described. There are results presented of prospective study of radiation synovectomy including recommendation of treatment indication. Further, this method is compared to other ones, from the point of view of the long term efficacy in retrospective study. Beneficial effect of...
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Hemostasis testing in children before ear-nose-throat surgery
Černá, Aneta ; Pařízková, Eva (advisor) ; Penka, Miroslav (referee) ; Komrska, Vladimír (referee)
Haemostasis testing in children before ear-nose-throat sugery Introduction: Haemorhagic complications in association with adenoidectomy and tonsillectomy are still a significant medical problem, despite development of surgical procedures and technology. The purpose of the preoperative coagulation tests is to identify patients with a bleeding disorder and therefore with a higher risk of bleeding. There is ongoing discussion about the most effective preoperative screening before ear-nose-throat surgery. The main aims of this study are: to find out the occurence of abnormal preoperative coagulation test results in paediatric patients before adenoidectomy and tonsillectomy, as well as to identify the most frequent causes of prolonged coagulation tests and to evaluate the influence of coagulation screening for further perioperative management. Patients and methods: Two cohorts of patients were evaluated. Cohort I.: In this prospective study coagulation tests were performed in children before adenoidectomy and tonsillectomy. A questionnaire was used for asking parents about the personal and family history of bleeding symptoms. The occurence of abnormal preoperative coagulation tests was evaluated, as well as the relationship to the peri/postoperative bleeding complications. Moreover a cohort of patients...
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