National Repository of Grey Literature 20 records found  previous11 - 20  jump to record: Search took 0.01 seconds. 
Developmental, pathobiochemical and molecular aspects of selected inborn errors of metabolism
Kolářová, Hana ; Honzík, Tomáš (advisor) ; Drahota, Zdeněk (referee) ; Morava Kozicz, Eva (referee)
Inborn errors of metabolism represent a heterogenous group of rare conditions, most having an incidence of less than 1 in 100,000 births. Because of their low prevalence, they are on the margin of attention of general research and even more so of large pharmaceutical companies. Study of rare diseases is the only way to design therapeutic options in order to improve quality of life of affected patients. Present Thesis particularly focuses on disturbances in mitochondrial energy metabolism. The main goals were the characterization of mitochondrial biogenesis within foetal development, as well as in childhood and adulthood. Another aim was to define clinical, biochemical and molecular aspects of mitochondrial optic neuropathies in childhood and adulthood. This work supported the earlier observations that gestational week 22 is the edge of viability, which has to be taken into account in upcoming discussions about guidelines on resuscitation of preterm neonates. Secondly, over last four years, we managed to examine and describe large cohort of patients with optic neuropathies based on a mitochondrial dysfunction. We have managed to characterize the biochemical and molecular-genetic background in more than 200 patients, and both selected cases (LHON/MELAS overlap syndrome) and cohort studies (MELAS,...
Polystyrene photoactive nanomaterials producing singlet oxygen
Henke, Petr ; Mosinger, Jiří (advisor) ; Dědic, Roman (referee) ; Kolářová, Hana (referee)
The increasing number of multidrug-resistant strains of bacteria call for alternatives to antibiotic therapy and, more generally, for the antimicrobial material as a component of prevention. Of particular interest is the photodynamic inactivation of bacteria and other pathogens caused by photogenerated singlet oxygen. This work is focused on the field of photoactive polymer nanofiber membranes and nanoparticles, generating singlet oxygen, suitable for medical applications. We prepared different types of photoactive modified polystyrene nanofiber membranes with encapsulated or externally bound porphyrin photosensitizers. These materials efficiently produce highly reactive and cytotoxic singlet oxygen capable of restricted diffusion into to the external environment. Our results demonstrate the crucial role of wettability for materials of this type with a short diffusion length of generated singlet oxygen, illustrate the effect of temperature and indicate their potential use as multifunctional materials. Due to their antimicrobial properties, these materials are suitable alternative to antibiotics and local antiseptics. With good breathability and short diffusion length of singlet oxygen good results can be expect in in vivo tests. From these nanofiber materials we also prepared photoactive extremely...
Analysis of the badminton match in women's singles
Kolářová, Hana ; Carboch, Jan (advisor) ; Kočíb, Tomáš (referee)
Title: Analysis of the badminton match in women's singles Objectives: The goal is to identify the most suitable choice a combinations of the first three shots, leading to the acquisition point between the server and the receiver among the best world woman players. And also to discover which was the usage of different types of serve, return and the third shot. Methods: Indirect analysis - videoanalysis Results: The results has shown that women prefer short forehand serve, most of the returns went into the front of the court, than most used shot was lob which tended into rear backhand court. The most played shot was lob into rear backhand court, which is interesting. Still woman players were more successful with the short shots at the net. Keywords: badminton, service, return, tactics, technique, characteristics of badminton
Detection and visualization of native and artificial chondrogenous tissue using biophysical methods
Rampichová, Michala ; Amler, Evžen (advisor) ; Rosina, Jozef (referee) ; Kolářová, Hana (referee)
Tissue engineering is a rapidly developing field, based on using scaffolds made from natural or synthetic materials in combination with cells and stimulating factors for the replacement of damaged or lost tissue. It is very important to evaluate qualities of these scaffolds, which are necessary for cell proliferation and their mechanical support. The aim of this study was to develop a suitable scaffold for chondrocyte proliferation, scaffold functionalization and detection of cells and proteins of extracellular matrix (ECM) using methods of fluorescence and confocal microscopy. Another aim was to test an appropriate scaffold on a big animal model in vivo. Several scaffolds from natural and synthetic materials, in the form of microfibers, non-woven textiles, gels and foams were prepared for this study. Scaffolds were seeded with chondrocytes and cell adhesion, proliferation and synthesis of ECM proteins were detected. Methods of fluorescence microscopy, confocal microscopy and second harmonic generation (SHG) were used for visualization of cells and proteins. A hydrogel based on fibrin and hyaluronan was used as an scaffold for osteochondral defect regeneration in minipigs study. Prepared scaffolds showed high biocompatibility, good chondrocyte adhesion and ECM proteins synthesis. Moreover, microfibrous...
Electronic support for learning. Use of the multiple steps e-learning concept in medical biophysics
Nosek, Tomáš ; Hanuš, Josef (advisor) ; Bolek, Lukáš (referee) ; Kolářová, Hana (referee)
Electronic support for learning -Use of the multiple steps e-learning concept in medical biophysics The aim of our work was to create and test a new concept of education based on modern e-learning methods. It should respond to our needs of higher individualization of education in terms of time, content and place. We named it the MSL concept - the Multiple Steps Learning concept. In the spirit of our concept we created three courses in LMS Moodle as support of practical education in Medical Biophysics. We started a pilot project to test the quality of the courses and their impact on knowledge of students. For evaluation of the courses we used our own modification of eLSE methodology. To test the impact on knowledge we compared the results of end-term tests between subsequent years - the education with and without e-learning support. The results of our pilot project show clearly that we created good quality courses. However, the impact of the new method on knowledge is not clear. According to the collected data the difference between both methods of education is not statistically significant but we experienced some serious problems during data acquisition and that is why the validity of the data is at least disputable. These problems gave rise to a new methodology of gained knowledge comparison which was an...
Risk factors for malignant neoplasms of skin and prevention options
Rosina, Jozef ; Čelko, Alexander (advisor) ; Kolářová, Hana (referee) ; Dohnal, Karel (referee) ; Navrátil, Leoš (referee)
Skin tumors are the most common types of tumors in humans. Their incidence is steadily increasing. Increases and mortality, especially in malignant melanoma. Risk factors playing an important role in the development of skin cancer, solar radiation belong. UV spectrum of sunlight is the most important cause of skin cancer. Therefore, the degradation of the ozone layer and the associated increased levels of UV radiation reaching the world so much studied. Among other known risk factors belong phenotype of human acute intermittent sunburn, especially in children and adolescents, increased tendency to form freckles skin after exposure to sunlight and the presence of pigmented nevi. Some people may find a genetic basis. The risk of malignant melanoma is also rising in people who have a history had already been diagnosed with this disease. Significant for the possibility of skin malignancy is immunosuppression. The work is focused on statistical analysis of most of the above mentioned risk factors.
The development of cross-border cooperation of the Region of South Bohemia, the Free State of Bavaria, Upper and Lower Austria with a focus on Strategy for removal of consequences of the Iron Curtain.
KOLÁŘOVÁ, Hana
The author of the bachelor thesis is going to handle with the development of the Region of South Bohemia, Free State of Bavaria and Upper and Lower Austria cross-border cooperation. The thesis concerns general problematic of cross-border cooperation, its historic development in the frame of the respective timeframe, concerning period from the year 1948 up to nowadays, further the projects administrated by the Region of South Bohemia and its neighbouring regions as well as the planning projects, not yet implemented. Introduction of The Strategy for Removing The Impacts of The Iron Curtain in the separate chapter enables deeper insight into the strategy as well as into its future utilization. Moreover, the author made questionnaire research among the citizens living in the border towns of the Region of South Bohemia that might feel the impacts of the iron curtain the most. In the conclusion of the thesis the author creates conclusions from the carried research and confirms or disputed the assumption of the thesis.
Stability of the field of view uniformity in gamma kamera Infinia
KOLÁŘOVÁ, Hana
The methods of field-of-view uniformity measurement on Infinia scintillation cameras as applied within the daily quality control exercise are described, and the results are evaluated against the limiting levels specified by the manufacturer. Uniformity is a basic parameter describing the scintillation camera image quality. In order to assure a smooth and continuous operation of nuclear medicine departments, instrumentation must comply with quality requirements for the examination of patients. For Infinia scintillation cameras the manufacturer recommends their planar integral uniformity to be tested on a day-by-day basis. Infinia cameras are parts of SPECT/CT systems. If the planar parameters of the SPECT system are not very good, planar imaging is slightly affected but SPECT images in the tomographic mode can be ruined altogether.Two methods exist for uniformity measurement, using either a point source of ionizing radiation or a planar source of ionizing radiation, respectively. The main objective of this project was to collect measuring data from several departments, compare them and ascertain whether the data exceed the limit specified by the manufacturer. From the field-of-view uniformity measurements it can be concluded unambiguously that the limits specified by the manufacturer of the Infinia scintillation cameras were never exceeded. In other words, the performance of the detection technology was never so poor as to affect adversely the diagnostic information derived from the system. In conclusion, information gained within this work attests to the reliability of Infinia scintillation cameras.
The expansion of small and medium-sized Czech enterprises into Austrian business market: the example of Cockyshop.cz
Kolářová, Hana ; Sztogrynová, Miroslava (advisor) ; Galan, Tomáš (referee)
Hlavním cílem práce je návrh vhodné marketingové strategie pro českou firmu Cockyshop.cz, která plánuje vstup na rakouský trh internetového prodeje kontaktních čoček. Práce je koncipovaná tak, aby mohla sloužit i jako obecný návod pro další české malé a střední podniky, které se chystají vstoupit na některý z trhů členských zemí Evropské unie. Navrhovaná opatření jsou založena nejen na důkladné analýze veřejně dostupných zdrojů, ale také na vlastních šetřeních provedených přímo na rakouském trhu.

National Repository of Grey Literature : 20 records found   previous11 - 20  jump to record:
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11 KOLÁŘOVÁ, Hana
4 KOLÁŘOVÁ, Helena
4 Kolářová, Helena
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