|
|
Pharmacotherapy of migraine
Koblásová, Anna ; Hrdina, Radomír (advisor) ; Herink, Josef (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Anna Koblásová Supervisor: Doc. MUDr. Hrdina Radomír, CSc. Title of diploma thesis: Pharmacotherapy of migraine Migraine is a highly prevalent disorder characterized by periodic, unilateral, pulsatile headaches that begin in childhood, adolescence or an early adult life. This common primary headache disorder presents a serious medical and socio-economic problem. Opinions concerning an etiopathogenesis of migraine develop gradually. A comprehensive management of headache includes the treatment of the acute attack to relieve the pain and prophylactic therapy to reduce the frequency, severity and duration of attacks. Triptans are considered as the firstline treatment for acute care of migraine attacks, in spite of this some patiens do not respond adequately. Triptans are in some cases ineffective, in other ones contraindicated. The greatest need is for the new specific drugs. Specific mechanisms that participate in pathophysiology of migraine have been discovered and drugs interacting with these mechanisms are registered in the market. Although attacks commonly diminish in severity and frequency with age, it may actually worsen in some postmenopausal women, and estrogen therapy may...
|
|
|
Copper reducing properties of flavanones
Koblásová, Anna ; Karlíčková, Jana (advisor) ; Jahodář, Luděk (referee)
1 ABSTRACT Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany and Ecology Candidate: Mgr. Anna Koblásová Consultant: PharmDr. Jana Karlíčková, Ph.D. Title of the Rigorous Thesis: Copper reducing properties of flavanones Copper is an essential trace element, an integral part of many important enzymes involved in a number of vital biological processes. It is necesarry for optimal antioxidant defense of organism. Excess or deficiency of copper cause impaired cellular functions. High concentrations of copper may increase oxidative damage to lipids, proteins, and DNA and contribute to neurodegenerative disorders. Copper deficiency decreases the body's ability to deal with oxidative stress. Free copper ions may catalyze the formation of highly reactive hydroxyl radicals, for that reason they are tight binding to protein carriers. Cuproenzymes are important members of the human antioxidant system. Flavonoids are a large group of polyphenolic compounds with antioxidant and chelating properties. They inhibit lipid peroxidation, formation of reactive oxygen species and chelate redox-active metals. These abilities are influenced by the number, positions, and types of substitutions. Flavonoids have generated an interest because of their broad pharmacological...
|
|
|
Pharmacotherapy of migraine
Koblásová, Anna ; Hrdina, Radomír (advisor) ; Herink, Josef (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Anna Koblásová Supervisor: Doc. MUDr. Hrdina Radomír, CSc. Title of diploma thesis: Pharmacotherapy of migraine Migraine is a highly prevalent disorder characterized by periodic, unilateral, pulsatile headaches that begin in childhood, adolescence or an early adult life. This common primary headache disorder presents a serious medical and socio-economic problem. Opinions concerning an etiopathogenesis of migraine develop gradually. A comprehensive management of headache includes the treatment of the acute attack to relieve the pain and prophylactic therapy to reduce the frequency, severity and duration of attacks. Triptans are considered as the firstline treatment for acute care of migraine attacks, in spite of this some patiens do not respond adequately. Triptans are in some cases ineffective, in other ones contraindicated. The greatest need is for the new specific drugs. Specific mechanisms that participate in pathophysiology of migraine have been discovered and drugs interacting with these mechanisms are registered in the market. Although attacks commonly diminish in severity and frequency with age, it may actually worsen in some postmenopausal women, and estrogen therapy may...
|
guest ::
RSS feed.