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Combination of Evolutionary Algorithms and Constraint Programming for Scheduling
Štola, Miroslav ; Pilát, Martin (advisor) ; Klíma, Martin (referee)
Scheduling problems and constraint satisfaction problems are generally known to be extremely hard. This thesis proposes a new evolutionary al- gorithm approach to solve a constrained-based scheduling problem. In this approach, variable orderings are evolved. The variable ordering serves as a parameter for the constraint solver. Its purpose is to determine the order in which variables are labelled by the solver. Hence the evolving individuals may be encoded as permutations. Therefore, our approach can be applied to a wider range of constraint satisfaction problems. Methods for generating the initial population of individuals based on the analysis of the precedence constraints graph are proposed. New genetic operators are presented and successfully applied. Our approach succeeded in finding a range of diverse schedules with the optimal makespan. Furthermore, multi-objective opti- mization was successfully attempted with the NSGA-II. 1
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Process analysis of nonconforming products
KLÍMA, Martin
Main goal of thesis is process analysis of nonconforming products and implementation of the corrective actions which will improve current status. Theoretical part presents history of quality, modern methods in quality, process of nonconforming products, preventive methods used in car industry and also the costs of quality. Practical part presents process analysis of nonconforming products in concrete company and main focus is implementation of the corrective actions. Main point regarding the improvement is upgrading detection system. Upgrade was made on concrete product, which represented huge quality extracosts.
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Optimalizace tvorby rolí pomocí RBAC modelu
KLÍMA, Martin
The aim of the thesis is to develop algorithm which will be able to optimize roles using RBAC model. The intent of the theoretical part is to analyze RBAC model and present current options which are available for role optimization. The practical part deals with development of algorithm which allows to optimize roles based on defined criteria from user. This algorithm is implemented in programming language Java and builds on Role Process Optimization Model (ROPM). In the last part is showed on example set of data how this algorithm works, step by step, with explanation of each step. Result of this algorithm is new RBAC model defined by user criteria. In this thesis are also listed different approach in role optimization, possible future development and concept of mapping RBAC model to mathematical and data-mining techniques.
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Molecular and functional characterization of the death receptor 6
Klíma, Martin
Death receptor-6 (DR6/TNFRsf21/CD358) is a receptor from the TNFR superfamily that likely participates in the regulation of proliferation and differentiation of T- and B-lymphocytes and neural cells. The 655-amino acid human DR6 is a type I transmembrane protein containing four cysteine-rich domains in its extracelular part and a death domain followed by the CARD-like region in its cytoplasmic part. Overexpression of DR6 in some cell lines leads to apoptosis, and/or to activation of nuclear factor NF-κB and stress kinases of the JNK family. In the first part of our work we focused on molecular characterization of DR6, including the analysis of its posttranslational modifications. We found that DR6 is an extensively posttranslationally modified protein including S-palmitoylation and both N- and O-glycosylation. Six N-glycosylation and one S-palmitoylation sites were precisely mapped to appropriate asparagines and cysteine respectively. The juxtaposed linker region (between cystein-rich domains and the transmembrane part), which also contains Ser/Thr/Pro-rich region with clustered putative O-glycosylation sites, is required for the plasma membrane localization of DR6. N-glycosylation, but interestingly not S-palmitoylation, may play a role in targeting of DR6 into detergent-resistant...
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Molecular and functional characterization of the death receptor 6
Klíma, Martin ; Anděra, Ladislav (advisor) ; Živný, Jan (referee) ; Kovář, Marek (referee)
Death receptor-6 (DR6/TNFRsf21/CD358) is a receptor from the TNFR superfamily that likely participates in the regulation of proliferation and differentiation of T- and B-lymphocytes and neural cells. The 655-amino acid human DR6 is a type I transmembrane protein containing four cysteine-rich domains in its extracelular part and a death domain followed by the CARD-like region in its cytoplasmic part. Overexpression of DR6 in some cell lines leads to apoptosis, and/or to activation of nuclear factor NF-κB and stress kinases of the JNK family. In the first part of our work we focused on molecular characterization of DR6, including the analysis of its posttranslational modifications. We found that DR6 is an extensively posttranslationally modified protein including S-palmitoylation and both N- and O-glycosylation. Six N-glycosylation and one S-palmitoylation sites were precisely mapped to appropriate asparagines and cysteine respectively. The juxtaposed linker region (between cystein-rich domains and the transmembrane part), which also contains Ser/Thr/Pro-rich region with clustered putative O-glycosylation sites, is required for the plasma membrane localization of DR6. N-glycosylation, but interestingly not S-palmitoylation, may play a role in targeting of DR6 into detergent-resistant...
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Effect of iron overload on the induction of apoptosis in mammalian cells
Kabíčková, Tereza ; Balušíková, Kamila (advisor) ; Klíma, Martin (referee)
Iron cations are an important metal ions required to number of essential cell functions. On the other hand, ferrous iron can be very toxic as well. When surplus iron is present in cells, it can catalyze the formation of reactive oxygen species (especially hydroxyl radicals) by Fenton reaction. Iron homeostasis is predominantly regulated by very strict mechanisms on the level of iron uptake into the body. Moreover, iron absorption, transport and storage within the body can be also regulated using complex mechanisms which differ on the level of individual cells and on the level of whole organism. Deregulation of iron homeostasis causing an iron overload and generation of reactive oxygen radicals can evoke serious cell damage leading up to apoptotic cell death. Excess iron storage and subsequent development of oxidative stress can affect lot of different tissues in the body. The organ damages such as fibrosis, cirrhosis, hepatocellular carcinoma, heart failure, loss of β cells and glucose intolerance or diabetes mellitus in patients with iron overload are very often seen. Nevertheless, the apoptosis induced by iron overload has not been well elucidated yet. There are no complex informations about the precise mechanism by which oxidative stress affects different cell types or whether there are other...
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Personal communicator for strategic sports
Válik, Martin ; Klíma, Martin (referee) ; Macháň, Ladislav (advisor)
The aim was to design connept of personal communicator useable for strategic sports such as airsoft or painball. Personal communicator provide wireless transmission of position provided by GPS module, eventually other data via RF module. Interactive user interface is solved by TFT touch display. For controlling of modules is used 32-bit ARM based microcontroller. The output is demonstration of functionality of communication and vizualization of distance between two designed devices on TFT display.
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Universal timer for sport activity
Janůš, Tomáš ; Klíma, Martin (referee) ; Macháň, Ladislav (advisor)
This bachelor thesis deals with a proposal and implementation of wireless electronic time measurement. In the thesis a proposal and implementation of simple wireless time measurement is described. Its part is also a proposal and creating of the optical barrier. The theoretical part further contains description and usage of various sensors. All sensors are wirelessly interconnected with the main device. The time measurement is being processed in the computer by means of a created programme which enables to control the time measurement and to save measured times as well.
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The via interconnection in LTCC
Sedliak, Erik ; Klíma, Martin (referee) ; Kosina, Petr (advisor)
This thesis deals with manufacturing process of LTCC 3D structures. Emphasis is placed mainly on the formation of via interconnections. In the second section of thesis, different via interconnections were designed, created and tested. Aim of this thesis was to evalute impact of via properties on vias function.
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