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Possibilities of influencing the healing and ligamentization of the graft during anatomical reconstruction of the anterior cruciate ligament - Results of the Prospective Randomised Study
Kasl, Jan ; Matějka, Jiří (advisor) ; Paša, Libor (referee) ; Pilný, Jaroslav (referee)
Aims Prospective, randomized, non-blinded study, on the effects of use of platelet-rich fibrin (PRF) in anterior cruciate ligament reconstruction surgery. Methods Initially, 40 patients between 2012 and 2014 were enrolled in the study and randomized for the treatment with (n=20, intervention group) or without (n=20) the use of PRF (controls). The average age was 29.1 years at inclusion, with 12 female and 28 male patients. Vivostat ® PRF was obtained from patient blood and applied onto the hamstring graft. Magnetic resonance imaging (MRI) documented healing was evaluated at 6 and 12 months. Clinical outcome parameters as well as standardized evaluation of knee laxity using the GenouRob device were collected at 12 months. Results Thirty-three patients completed the full follow-up (17 intervention, 16 control). In two cases, a graft tear was documented (occurred in the control group). However, there were no differences in the remodeling progress in MRI using the log-rank test (p=0.07). There was no difference in the return to pre-injury sport levels (p=0.232), Lysholm and IKDC scores (p=0.259 and p=0.364 respectively). Knee laxity measurements showed no differences between the intervention and control groups. Discussion Similar results we found in our study have recently been published by other world...
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The role of stakeholders in urban renewal and brownfields regeneration in Holešovice and Libeň
Rathová, Adéla ; Perlín, Radim (advisor) ; Kasl, Jan (referee)
This thesis deals with the roles of various stakeholders in urban development process and simultaneously with the process of transformation and brownfields regeneration in inner part of Prague. The area of case study, lower Holešovice and lower Libeň, has unique specifics: location is close to the city center and also to Vltava River and has a number of development areas. The thesis is based in theoretical foundations of urban regeneration, brownfields, concepts of urban development and systems of governance. The aim is to find out who are the most important stakeholders of urban development and their impact on the area of the case study. The practical part of the thesis is based on interviews with multiple stakeholders from public, private and non-profit sector as well as on an analysis of Prague`s official planning documentation. The results of the thesis underline different approach and engagement of various stakeholders, but also the assumption of significant changes in functional land use, structure and appearance of the area. Key words: urban regeneration - brownfields - urban planning - stakeholders of urban development - Holešovice - Libeň - Prague
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