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Gut microbiome and autoimmune mechanisms in patients with type 1 narcolepsy
Ježková, Janet ; Roubalová, Radka (advisor) ; Hrdý, Jiří (referee)
Narcolepsy Type 1 (NT1) is a chronic neurological disease characterized by the presence of cataplexy and excessive daytime sleepiness. NT1 probably arises from autoimmune destruction of orexinergic neurons in the hypothalamus. These neurons are the only known producers of the neuropeptides orexin A and B, which are involved in the regulation of sleep and wakefulness. NT1 is often accompanied by comorbidities such as obesity, type 2 diabetes, hormonal disorders, depression, and anxiety. Gut microbiota affects the quality of sleep by the production of various metabolites. It is considered that it may be involved in the pathogenesis of NT1 or in the development of related comorbidities. In our study, we analyzed the gut microbiota composition of 41 NT1 patients and 32 healthy controls using next-generation sequencing. The diversity of patients' gut microbiota did not differ significantly from healthy controls. In patients, we revealed a positive correlation between the abundance of the bacterial family Coriobacteriaceae, BMI, and the disease duration. Besides, we observed a negative correlation between the Coriobacteriaceae family and cholesterol levels, suggesting that these bacteria are involved in host lipid metabolism. Compared to healthy controls, a higher abundance of bacteria from the families...
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