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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Use of a Solid Bismuth Drop Electrode in the Determination of the Drug Metronidazole
 Jarošová, Johanka ; Vyskočil, Vlastimil (advisor) ; Fischer, Jan (referee)
The subject of the present Bachelor Thesis was the study of a new commercial solid bismuth drop electrode (SBiDE) and its use to find optimal conditions for the voltammetric determination of the drug metronidazole using the differential pulse voltammetry technique (DPV). The voltammetric behavior of the selected drug was studied as a function of pH of aqueous Britton-Robinson buffer (BR buffer) solution. BR buffer at pH 12 was chosen as the optimal medium for the determination of the drug metronidazole on SBiDE, in which the concentration dependence of metronidazole was measured in the range of 1×10−6 - 6×10−4 mol/L. The limit of quantification (LQ) was 1.38×10−6 mol/L and the limit of detection (LD) was 4.41×10−7 mol/L. The newly developed voltammetric method was used for the determination of metronidazole in the pharmaceutical forms Efloran infusion solution 500 mg/100 mL, Entizol 250 mg tablet, Entizol 500 mg vaginal tablet and Noridem infusion solution 500 mg/100 mL. The selected voltammetric method was compared with the analytical method by UV-VIS absorption spectrometry in the environment of aqueous BR buffer solution at pH 12 in the concentration range of metronidazole 2×10−5 - 8×10−5 mol/L.
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See also: similar author names
21 JAROŠOVÁ, Jana
21 Jarošová, Jana
2 Jarošová, Jitka
1 Jarošová, Jiřina
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