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National Repository of Grey Literature

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Growth hormone - IGF - 1 axis, it's regulation and function. Plasma ghrelin levels in certain pathologic states Jarkovská, Zuzana ; Marek, Josef (advisor) ; Hainer, Vojtěch (referee) ; Mareš, Jan (referee) Ghreliu is a peptide hormone with a strong stimulatory effect on growth hormone (GH) secretion. Ghrelin was origiu;i!íy isolated from the rat stomach as an endogenous secretagogue for the growth hormone secretagogue receptor (GHS-R). Although the fírst coinpoimds of the group of growth hormone seeretagogues were synthesized already in 1997, the isolation of the GHS-R and ghrelin is a matter of tlie last decade. Our study was aimed at the determination of the physiological role of endogenous ghrelin in GH secretion in certain pathological conditions and its associations with tlie GH/IGF-1 axis compounds. Our study was the first one detecíing also active ghrelin coucentrations. We assumed, that ghrelin secretion is aflected by the GH secretory statě. In patíents with acroinegaly we expected low ghrelin coucentrations (hypothesis 1) aud in patients with GHD we presuined, that ghrelin concentrations will be elevated (hypothesis 2) in comparison with healthy subjects as an effect of the negative feedback regulation by GH. Our findings however did not support tliese hypotheses, active and total ghrelin concentrations did not differ between patients and healthy controls. These data do not support an important role tor ghrelin in GH secretion in these conditions as well as the existence of a negative feedback... Detailed record

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2	Jarkovská, Zlata

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