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Zhodnocení antioxidační aktivity lipofilních esterů hydroxytyrosylu
Jarkovská, Stanislava ; Mladěnka, Přemysl (advisor) ; Martin, Jan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Stanislava Jarkovská Supervisors: Prof. Sandra Incerpi, Dr. Přemysl Mladěnka Title of diploma thesis: Evaluation of antioxidant activity of hydroxytyrosyl lipophilic esters Scavengers of reactive oxygen and nitrogen species (RONS) or shortly antioxidants could have beneficial effects in diseases associated with oxidative stress. In addition, antioxidants are widely used today for stabilization of fats and oils in food matrices. Hydroxytyrosol, the main phenolic compound of olive oil, possesses strong antioxidant activity. Due to its highly polar nature it is less soluble in lipophilic environment that limits its use as antioxidant in foods and in prevention/treatment of diseases. The aim of this thesis was to compare scavenging potential of parent compound hydroxytyrosol to its lipophilic esters with different side chain length. Antioxidant capacity of these esters that were synthetized in the Laboratory of Chemistry, Department of Mechanical and Industrial Engineering in university Roma Tre, were examinated in vitro in 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid diammonium salt (ABTS) radical scavenging assay and in L6-myoblasts in culture dichloroflourescein (DCF)...
Assesment of Iron Chelation by 4-Acyl-5-Pyrazolones by Direct Spectrophotometry
Jarkovská, Stanislava ; Mladěnka, Přemysl (advisor) ; Chocholouš, Petr (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Stanislava Jarkovská, MSc. Consultant: Přemysl Mladěnka, Ph.D. Title of Thesis: Assessment of iron chelation by 4-acyl-5-pyrazolones by direct spectrophotometry. Iron chelators are used to treat a variety of acquired or inherited hematological disorders and diseases, in which the human body is overloaded by dangerous iron. This pathological deviation is observed mostly in patients with anemias treated with regular blood transfusions. Iron accumulation leads significantly to increased morbidity and mortality if untreated. At present, other potential indications of iron chelators are intensively studied, especially the treatment of acute myocardial infarction, certain types of cancer or malaria. In the first two tested indications, pH drop plays an important role. The subject of this thesis is to verify the iron-chelating properties of selected chelators from 4-acyl-5-pyrazolone group by use of direct spectrophotometry at different pathophysiologically important pHs. Two substances were chosen from this chemical group - phenyl- and thienylderivatives of the basic structure, whose chelating properties had been successfully verified using ferrozine screening method. Both of the tested...
Zhodnocení antioxidační aktivity lipofilních esterů hydroxytyrosylu
Jarkovská, Stanislava ; Martin, Jan (referee) ; Mladěnka, Přemysl (advisor)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Stanislava Jarkovská Supervisors: Prof. Sandra Incerpi, Dr. Přemysl Mladěnka Title of diploma thesis: Evaluation of antioxidant activity of hydroxytyrosyl lipophilic esters Scavengers of reactive oxygen and nitrogen species (RONS) or shortly antioxidants could have beneficial effects in diseases associated with oxidative stress. In addition, antioxidants are widely used today for stabilization of fats and oils in food matrices. Hydroxytyrosol, the main phenolic compound of olive oil, possesses strong antioxidant activity. Due to its highly polar nature it is less soluble in lipophilic environment that limits its use as antioxidant in foods and in prevention/treatment of diseases. The aim of this thesis was to compare scavenging potential of parent compound hydroxytyrosol to its lipophilic esters with different side chain length. Antioxidant capacity of these esters that were synthetized in the Laboratory of Chemistry, Department of Mechanical and Industrial Engineering in university Roma Tre, were examinated in vitro in 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid diammonium salt (ABTS) radical scavenging assay and in L6-myoblasts in culture dichloroflourescein (DCF)...

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3 Jarkovská, Stanislava
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