|
|
Effect of combination of mucoadhesive polymers on the behaviour of matrix tablets in the small intestine
Janoušek, Miroslav ; Vraníková, Barbora (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Mentor: PharmDr. Barbora Vraníková, Ph.D. Consultant: Mgr. Chiazor Ugo Ogadah Student: Miroslav Janoušek Title of Thesis: Effect of combination of mucoadhesive polymers on the behaviour of matrix tablets in the small intestine Colon-targeted drug delivery is highly desirable due to the direct treatment of local intestinal diseases, drug dose reduction, and minimization of systemic adverse effects. This effect can be achieved by several specific drug delivery systems based on different mechanisms. Generally, the most preferred are orally administrated formulations due to the relatively easy manufacturing and high adherence of patients to treatment. These include matrix systems based on mucoadhesive polymers that allow both targeting to the desired site (e.g. colon) and controlled drug release. For the above-mentioned reasons, the aim of the presented study was to evaluate the behavior of two mucoadhesive polymers, namely guar gum (GK), hypromellose K15M (HPMC K15M) and their combinations in biorelevant media simulating small intestine fluids (FaSSIF). The viscosity of the polymer dispersions was measured using a rotational rheometer. Polymer formulations (compacts) containing the model drug...
|
|
|
Effect of combination of mucoadhesive polymers on the behaviour of matrix tablets in the small intestine
Janoušek, Miroslav ; Vraníková, Barbora (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Mentor: PharmDr. Barbora Vraníková, Ph.D. Consultant: Mgr. Chiazor Ugo Ogadah Student: Miroslav Janoušek Title of Thesis: Effect of combination of mucoadhesive polymers on the behaviour of matrix tablets in the small intestine Colon-targeted drug delivery is highly desirable due to the direct treatment of local intestinal diseases, drug dose reduction, and minimization of systemic adverse effects. This effect can be achieved by several specific drug delivery systems based on different mechanisms. Generally, the most preferred are orally administrated formulations due to the relatively easy manufacturing and high adherence of patients to treatment. These include matrix systems based on mucoadhesive polymers that allow both targeting to the desired site (e.g. colon) and controlled drug release. For the above-mentioned reasons, the aim of the presented study was to evaluate the behavior of two mucoadhesive polymers, namely guar gum (GK), hypromellose K15M (HPMC K15M) and their combinations in biorelevant media simulating small intestine fluids (FaSSIF). The viscosity of the polymer dispersions was measured using a rotational rheometer. Polymer formulations (compacts) containing the model drug...
|
guest ::
RSS feed.