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The effects of psilocybin assisted therapy on analytical rumination.
Vykoukal, Max ; Janošková, Marcela (advisor) ; Michalec, Jiří (referee)
Psilocybin is a psychedelic substance that shows affinity to serotonin 5HT2A receptors. It induces profound changes in everyday consciousness, including mystical-like experiences. Due to its properties, psilocybin has shown therapeutic potential for the treatment of various clinical disorders, especially treatment resistant depression. One of the factors that influence the onset and duration of depression are ruminations, i.e., our tendency to rigidly dwell upon the self and personal problems. Analytical rumination is a productive feature of this process in which an individual reflects upon the causes and potential solution to his/her problems. If uninterrupted and successful, analytical rumination can lead to increases in one's wellbeing. No studies have given attention to the relationship between psilocybin and analytical rumination. For that reason, the present thesis examined the effects of the compound on this process in 16 healthy participants. The data was provided by the Czech National institute of Mental Health (NIMH CZ). It was found that psilocybin bears no statistically significant effect on analytical rumination, although taken face value, the results appear to suggest that psilocybin may lead to a decrease in this form of cognition. In order to avoid a Type II error, future studies...
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