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2D and 3D models based on patients temporomandibular joint diseases
Hliňáková, Petra ; Dostálová, Taťjana (advisor) ; Mazánek, Jiří (referee) ; Hrušák, Daniel (referee)
The temporomandibular joint (TMJ) is one of the most complex joints in the body. Its harmony is established by coordination between occlusion, muscle, and joint. Changing lifestyles, decreasing physical activity, which is increasing the number of degenerative joint diseases of various etiologies, and certain dental procedures, are increasing the number of patients complaining of pain or other problems in their temporomandibular joints. Estimated 42% of the population is affected and 2-5,5 % is seeking treatment. Temporomandibular disorders (TMD) are clinical problems that involve the masticatory muscles, the temporomandibular joints and associated anatomical structures. Typical signs and symptoms of TMD are facial pain, clicking or crepitation of the TMJs, limited jaw opening capacity and deviation in the movement patterns of the mandible. The basis of successful treatment is a determination of the patient's causal problems. The analysis is based on the model of the ideal biomechanics of TMJ. The rehabilitation of temporomandibular joint disorders needs comprehensive long-term therapy based mainly on physical, surgical, and prosthetic treatment. Detailed knowledge about the function and morphology of temporomandibular joint are necessary for clinical evaluation and treatment of temporomandibular...
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Bone Augmentation Materials Evaluation of Implant Osteointegration
Moztarzadeh, Omid ; Hrušák, Daniel (advisor) ; Vaněk, Jiří (referee) ; Pazdera, Jindřich (referee)
Bone Augmentation Materials Evaluation of Implant Osteointegration This dissertation thesis contains a description and results of six constituent studies. The first study was performed in order to investigate the most common indications for the use of three bone augmentation materials, Biogen, Cerasorb and Bioresorb. The most common indications identified were based on statistical data collected from patients treated at the Maxillofacial Surgery Department, Faculty Hospital in Pilsen, during 2003-2007. The second experiment was performed in vivo. We evaluated the possible osteoinduction potential and osteogenic activities of two different bone augmentation materials (Cerasorb, Biogen) by examining whether ectopic bone formation could be induced when implanted subcutaneously into the extremities of our test subjects (pigs). The results obtained, highlight the potential future use, of augmentation materials in creation of hard tissues, in areas where soft tissues are normally present. The third experiment was performed in order to evaluate the efficiency of Cerasorb bone augmentation material in bone healing. Cerasorb was applied into an artificial hole in the extremities of the test subjects and based on careful analysis of the radiographic and histological images, we found that Cerasorb gradually resorbed...
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Thyroid Dysfunction after Radiotherapy of Head and Neck Cancer
Bernát, Ladislav ; Hrušák, Daniel (advisor) ; Fínek, Jindřich (referee) ; Jenča, Andrej (referee)
Objectictives: Radiation therapy is often applied to patients with head and neck cancer because of a high sensitivity to these cancers. It improves treatment outcomes and permits the preservation of functions and physical form. However, it has been shown that various complications can result from radiation therapy. Hypothyroidism can be one of them as the thyroid gland is frequently included in radiation fields. In spite of that, thyroid hypofunction is not commonly considered a complication of radiotherapy for head and neck cancer. The purpose of this retrospective study was to determine the frequency of thyroid dysfunction in patients after radiotherapy, to compare thyroid hormone levels in irradiated patients with control group and to predict development of thyroid hypofunction in time. Material and method: Thyroid function was measured by means of thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodthyronine (FT3) in 43 patiens who had nonthyroid head-neck carcinomas treated by radiotherapy or radiotherapy in combination with other treatment modalities. These data were compared with hormone levels of 40 control group patients treated solely by surgery. Results: In median follow-up period 34 months after radiation, hypothyroidism was found in 35% of irradiated patients. In...
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Biocompatibility of Implantable MaterialsFocused on Titanium Dental Implants
Moztarzadeh, Amin ; Babuška, Václav (advisor) ; Hrušák, Daniel (referee) ; Chocholatý, Ondřej (referee)
This dissertation thesis deals with the evaluation of biocompatibility and osseointegration of nanostructured titanium materials used for dental implants. Bulk material topography and surface modification of titanium are currently of intense research mainly due to the significant impact on biocompatibility and improvement of osseointegration of dental implants. In the theoretical part are described types of titanium material and different methods of its surface modification. In vitro and in vivo biocompatibility and osseointegration tests are described as well. The experimental work consists of two parts of experiments. In the first experiment, we examined how grain size of nanostructured titanium material influences the behaviour of fibroblastic as well as osteoblastic cells growth on its surface. The experimentally obtained data were statistically analysed and discussed. Grain size was proven to be an important factor that influenced not only the strength of material but also its interactions with cells. The second experiment describes current methods used in the experimental evaluation of osseointegration of dental implants. The results of histological staining methods are illustrated and compared. A standardized and reproducible technique for stereological quantification of bone-implant contact...
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Biocompatibility of Implantable Materials Focused on Titanium Dental Implants
Moztarzadeh, Amin ; Babuška, Václav (advisor) ; Hrušák, Daniel (referee) ; Chocholatý, Ondřej (referee)
This dissertation thesis deals with the evaluation of biocompatibility and osseointegration of nanostructured titanium materials used for dental implants. Bulk material topography and surface modification of titanium are currently of intense research mainly due to the significant impact on biocompatibility and improvement of osseointegration of dental implants. In the theoretical part are described types of titanium material and different methods of its surface modification. In vitro and in vivo biocompatibility and osseointegration tests are described as well. The experimental work consists of two parts of experiments. In the first experiment, we examined how grain size of nanostructured titanium material influences the behaviour of fibroblastic as well as osteoblastic cells growth on its surface. The experimentally obtained data were statistically analysed and discussed. Grain size was proven to be an important factor that influenced not only the strength of material but also its interactions with cells. The second experiment describes current methods used in the experimental evaluation of osseointegration of dental implants. The results of histological staining methods are illustrated and compared. A standardized and reproducible technique for stereological quantification of bone-implant contact...
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2D and 3D models based on patients temporomandibular joint diseases
Hliňáková, Petra ; Dostálová, Taťjana (advisor) ; Mazánek, Jiří (referee) ; Hrušák, Daniel (referee)
The temporomandibular joint (TMJ) is one of the most complex joints in the body. Its harmony is established by coordination between occlusion, muscle, and joint. Changing lifestyles, decreasing physical activity, which is increasing the number of degenerative joint diseases of various etiologies, and certain dental procedures, are increasing the number of patients complaining of pain or other problems in their temporomandibular joints. Estimated 42% of the population is affected and 2-5,5 % is seeking treatment. Temporomandibular disorders (TMD) are clinical problems that involve the masticatory muscles, the temporomandibular joints and associated anatomical structures. Typical signs and symptoms of TMD are facial pain, clicking or crepitation of the TMJs, limited jaw opening capacity and deviation in the movement patterns of the mandible. The basis of successful treatment is a determination of the patient's causal problems. The analysis is based on the model of the ideal biomechanics of TMJ. The rehabilitation of temporomandibular joint disorders needs comprehensive long-term therapy based mainly on physical, surgical, and prosthetic treatment. Detailed knowledge about the function and morphology of temporomandibular joint are necessary for clinical evaluation and treatment of temporomandibular...
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Thyroid Dysfunction after Radiotherapy of Head and Neck Cancer
Bernát, Ladislav ; Hrušák, Daniel (advisor) ; Fínek, Jindřich (referee) ; Jenča, Andrej (referee)
Objectictives: Radiation therapy is often applied to patients with head and neck cancer because of a high sensitivity to these cancers. It improves treatment outcomes and permits the preservation of functions and physical form. However, it has been shown that various complications can result from radiation therapy. Hypothyroidism can be one of them as the thyroid gland is frequently included in radiation fields. In spite of that, thyroid hypofunction is not commonly considered a complication of radiotherapy for head and neck cancer. The purpose of this retrospective study was to determine the frequency of thyroid dysfunction in patients after radiotherapy, to compare thyroid hormone levels in irradiated patients with control group and to predict development of thyroid hypofunction in time. Material and method: Thyroid function was measured by means of thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodthyronine (FT3) in 43 patiens who had nonthyroid head-neck carcinomas treated by radiotherapy or radiotherapy in combination with other treatment modalities. These data were compared with hormone levels of 40 control group patients treated solely by surgery. Results: In median follow-up period 34 months after radiation, hypothyroidism was found in 35% of irradiated patients. In...
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Bone Augmentation Materials Evaluation of Implant Osteointegration
Moztarzadeh, Omid ; Hrušák, Daniel (advisor) ; Vaněk, Jiří (referee) ; Pazdera, Jindřich (referee)
Bone Augmentation Materials Evaluation of Implant Osteointegration This dissertation thesis contains a description and results of six constituent studies. The first study was performed in order to investigate the most common indications for the use of three bone augmentation materials, Biogen, Cerasorb and Bioresorb. The most common indications identified were based on statistical data collected from patients treated at the Maxillofacial Surgery Department, Faculty Hospital in Pilsen, during 2003-2007. The second experiment was performed in vivo. We evaluated the possible osteoinduction potential and osteogenic activities of two different bone augmentation materials (Cerasorb, Biogen) by examining whether ectopic bone formation could be induced when implanted subcutaneously into the extremities of our test subjects (pigs). The results obtained, highlight the potential future use, of augmentation materials in creation of hard tissues, in areas where soft tissues are normally present. The third experiment was performed in order to evaluate the efficiency of Cerasorb bone augmentation material in bone healing. Cerasorb was applied into an artificial hole in the extremities of the test subjects and based on careful analysis of the radiographic and histological images, we found that Cerasorb gradually resorbed...
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