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Tooth extractions in patients with coagulation disorder
Houba, Robert ; Houbová, Helena (advisor) ; Vaněk, Jiří (referee) ; Stanko, Peter (referee)
The study deals with the question of minor oral surgery procedures, dental extractions especially, in patients suffering from haemocoagulation disorder. The aim of this study was 1) the clinical attestation of the risk of bleeding that may follow the dental extraction in patients with non-interrupted oral administration of drugs with the anticoagulant and antiplatelet effects and 2) suggestion of the schedules of surgical procedures suitable for this kind of patients and for the realization in the standard dental office. The opening theoretical part analyses the principle of haemocoagulation, the surway of individual inherited and acquired bleeding disorders and the main principles of treatment of bleeding patients in dental offices with the emphasis on the local security of the surgical wound. In the proper study we present the observation and evaluation of bleeding complications after the standard dental extractions in 3 groups of persons (age range, 19 to 93 years). In all patients, one or more extractions were performed. 99 patients were treated with oral anticoagulant therapy without any interruption and underwent 199 extractions. 149 patients, treated with antiplatelet therapy (acetylsalicylic acid) without interruption, underwent 347 extractions. 160 healthy subjects with 316 extractions served as a...
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Oral lichen planus - clinical and laboratory parameters
Radochová, Vladimíra ; Slezák, Radovan (advisor) ; Houbová, Helena (referee) ; Kerekes, Zoltán (referee)
in English - MUDr. Vladimíra Radochová Presented work deals in the first plase with clinical evaluation of patients with OLP regarding clinical presentation, gender, age and various clinical presentation of the disease. The necessity of the treatment and therapeutic approach is stressed as well. The following parts deal with systematic research of possible etiopathogenetic mechanisms of OLP. Research part is divided into chapters dealing with cytochrome P450 2D6 metabolism and drug use in patients with OLP. Further the importance of matrix metalloproteinase 9 in the development of OLP is discussed. The last part is focused on presence of HPV in OLP lesions. Demographic data of our cohort of patients are consistent with previously published data from around the world. Occurence of clinical forms, necessity of treatment are also in concordance with previously published data. Our data show the same metabolic rates of cytochrome P450 2D6 in patients with OLP compared to healthy Czech population. Drug use is similar to matched age and sex controls. We therefore were unable to confirm the role of different metabolic pathways in OLP. MMP 9 is higly expressed in OLP lesions. This probably represents general inflammatory process which takes part in OLP developement. We observe high positivity of HPV in OLP...
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Tooth extractions in patients with coagulation disorder
Houba, Robert ; Houbová, Helena (advisor) ; Vaněk, Jiří (referee) ; Stanko, Peter (referee)
The study deals with the question of minor oral surgery procedures, dental extractions especially, in patients suffering from haemocoagulation disorder. The aim of this study was 1) the clinical attestation of the risk of bleeding that may follow the dental extraction in patients with non-interrupted oral administration of drugs with the anticoagulant and antiplatelet effects and 2) suggestion of the schedules of surgical procedures suitable for this kind of patients and for the realization in the standard dental office. The opening theoretical part analyses the principle of haemocoagulation, the surway of individual inherited and acquired bleeding disorders and the main principles of treatment of bleeding patients in dental offices with the emphasis on the local security of the surgical wound. In the proper study we present the observation and evaluation of bleeding complications after the standard dental extractions in 3 groups of persons (age range, 19 to 93 years). In all patients, one or more extractions were performed. 99 patients were treated with oral anticoagulant therapy without any interruption and underwent 199 extractions. 149 patients, treated with antiplatelet therapy (acetylsalicylic acid) without interruption, underwent 347 extractions. 160 healthy subjects with 316 extractions served as a...
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