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Long Pentraxin 3 - a Putative Biomarker with Predictive Value to Identify the Adverse Inflammatory Response in Cardiac Surgical Patients?
Holubcová, Zdeňka ; Manďák, Jiří (advisor) ; Lonský, Vladimír (referee) ; Rohn, Vilém (referee)
(LONG PENTRAXIN 3 - A PUTATIVE BIOMARKER WITH PREDICTIVE VALUE TO IDENTIFY THE ADVERSE INFLAMMATORY RESPONSE IN CARDIAC SURGICAL PATIENTS?) INTRODUCTION. Cardiac surgery is well established for development of systemic inflammatory response. There are still no biomarkers with significant predictive value to identify patients at risk. AIM. The aim of this study was to compare the dynamics of pentraxin 3 (PTX3) and other inflammatory biomarkers (CRP, TLR2 and IL-8) after cardiac surgery with particular regards to different postoperative clinical manifestation of inflammatory response. Furthermore to evaluate the association between perioperative inflammatory biomarkers (PTX3, CRP, IL-8, IL-18, IL-18BP, TLR2, MMP7, MMP8, sFas a sFasL) and atrial fibrillation (AF) in cardiosurgical patients. METHODS. Forty-two patients undergoing open heart surgery with the use of cardiopulmonary bypass were included in the study and divided in 2 groups according to the extent of clinical manifestation of inflammatory response: Group A (n = 21) - patients with different severity of systemic inflammatory response syndrome (SIRS) and Group B (n = 21) - patients with uneventful postoperative period (no SIRS). The same group of 42 patient were divided in 3 groups according to occurrence of atrial fibrillation (AF): Group A...
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Long Pentraxin 3 - a Putative Biomarker with Predictive Value to Identify the Adverse Inflammatory Response in Cardiac Surgical Patients?
Holubcová, Zdeňka ; Manďák, Jiří (advisor) ; Lonský, Vladimír (referee) ; Rohn, Vilém (referee)
(LONG PENTRAXIN 3 - A PUTATIVE BIOMARKER WITH PREDICTIVE VALUE TO IDENTIFY THE ADVERSE INFLAMMATORY RESPONSE IN CARDIAC SURGICAL PATIENTS?) INTRODUCTION. Cardiac surgery is well established for development of systemic inflammatory response. There are still no biomarkers with significant predictive value to identify patients at risk. AIM. The aim of this study was to compare the dynamics of pentraxin 3 (PTX3) and other inflammatory biomarkers (CRP, TLR2 and IL-8) after cardiac surgery with particular regards to different postoperative clinical manifestation of inflammatory response. Furthermore to evaluate the association between perioperative inflammatory biomarkers (PTX3, CRP, IL-8, IL-18, IL-18BP, TLR2, MMP7, MMP8, sFas a sFasL) and atrial fibrillation (AF) in cardiosurgical patients. METHODS. Forty-two patients undergoing open heart surgery with the use of cardiopulmonary bypass were included in the study and divided in 2 groups according to the extent of clinical manifestation of inflammatory response: Group A (n = 21) - patients with different severity of systemic inflammatory response syndrome (SIRS) and Group B (n = 21) - patients with uneventful postoperative period (no SIRS). The same group of 42 patient were divided in 3 groups according to occurrence of atrial fibrillation (AF): Group A...
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