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National Repository of Grey Literature

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Změny EKG u potkana s indukovanou remodelací myokardu: Význam, komplexnost a optimalizace animálních experimentů Stračina, Tibor ; Laška, Michal ; Nádeníček, Jaroslav ; Hendrych, Michal ; Nováková, Marie Navzdory pokročilým nástrojům matematického modelování a zpracování dat jsou experimenty s využitím pokusných zvířat pořád nezastupitelnou součástí biomedicínského výzkumu. Tento příspěvek prezentuje model myokardiální remodelace u potkana indukovaný tlakově-objemovým přetížením s mineralokortikoidní stimulací. Cílem prezentované studie bylo popsat změny EKG křivky u potkanů s indukovanou remodelací myokardu pomocí DOCA/salt modelu. Zároveň se studie zaměřila na optimalizaci modelu s cílem snížit riziko tkáňových otoků a zpomalit rozvoj srdečního selhání. V neposlední řadě si příspěvek klade za cíl poukázat na význam a komplexnost experimentů s využitím pokusných zvířat. Detailed record

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6	Hendrych, Marek
1	Hendrych, Milan
1	Hendrych, Miroslav

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