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Compressibility of different batches of the drug Simvastatin.
Havelková, Adéla ; Řehula, Milan (advisor) ; Ondrejček, Pavel (referee)
This thesis deals with the characterization of pressing energy using the force-displacement diagram. The theoretical part defines the substance - simvastatin - and excipients which could occur in unknown samples. Also energies of pressing process, methods of assessment of force-displacement diagram for different substances and factors which affect pressability and thus the pressing energy are described there. The aim of the experimental part of the thesis was to characterize the energy profile using force-displacement diagram of eight batches of preparation simvastatin and to find applicable method of assessment. Tablets were pressed from each batch of preparations using a T1-FRO 50 machine at three pressing forces 5, 10, and 15 kN. Obtained parameters E2, E3, Elis and Pl were evaluated using three methods: method of outlying values, method of analysis of average for one factor and method of analysis of average for two factors. The most suitable method for assessment of divergent values is the method of analysis of average for two factors thanks to its complex character. This method showed lower values of the parameters E1, E2, Elis and Pl for batches E, G and H which could be caused by larger particles and higher moisture of granulate.
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The credibility of testimony in criminal proceedings
Havelková, Adéla ; Čírtková, Ludmila (advisor) ; Krupička, Jiří (referee)
66 The credibility of testimony in criminal proceedings Abstract This thesis focuses on assessing the credibility of testimony in criminal proceedings with a closer focus on assessing the credibility of testimony by investigative, prosecuting and adjudicating bodies. For this purpose, in the first part of the thesis, the author defines the term "testimony", describes its role in the criminal proceeding and distinguishes its role in the criminal proceeding as opposed to that in the civil proceeding. Then, the author defines the term "interrogation" and identifies institutes of criminal law applied in the course of criminal proceedings, by which the testimony is obtained. In the following, third chapter, the author focuses on the explanation of the concept of credibility of testimony, and differentiates its various types. In the fourth and fifth chapter, the author identifies, describes and evaluates possible ways of assesing the credibility of testimony by investigative, prosecuting and adjudicating bodies in context of current case law. Special attention is paid to expertises, their assignment, interpretation and evaluation. The author analyzed current legislation and case law, and the options they offer for assessing the credibility. The formulated hypotheses have been confirmed. Current legislation...
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Compressibility of different batches of the drug Simvastatin.
Havelková, Adéla ; Řehula, Milan (advisor) ; Ondrejček, Pavel (referee)
This thesis deals with the characterization of pressing energy using the force-displacement diagram. The theoretical part defines the substance - simvastatin - and excipients which could occur in unknown samples. Also energies of pressing process, methods of assessment of force-displacement diagram for different substances and factors which affect pressability and thus the pressing energy are described there. The aim of the experimental part of the thesis was to characterize the energy profile using force-displacement diagram of eight batches of preparation simvastatin and to find applicable method of assessment. Tablets were pressed from each batch of preparations using a T1-FRO 50 machine at three pressing forces 5, 10, and 15 kN. Obtained parameters E2, E3, Elis and Pl were evaluated using three methods: method of outlying values, method of analysis of average for one factor and method of analysis of average for two factors. The most suitable method for assessment of divergent values is the method of analysis of average for two factors thanks to its complex character. This method showed lower values of the parameters E1, E2, Elis and Pl for batches E, G and H which could be caused by larger particles and higher moisture of granulate.
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