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The role of NADPH oxidase and ros in invadopodia formation
Hanušová, Kristýna ; Brábek, Jan (advisor) ; Vrbacký, Marek (referee)
Invadopodia as specific organelles enabling tumour cells movement, spreading over the organism and ultimately formation of metastasis are possible and promising targets of tumour therapy. Recently, many interesting facts about assembly and mechanism of function of invadopodia were discovered. Invadopodia are centres of ECM degradation by extra-cellular proteases facilitating an invasion of tumour cells. For creation of invadopodia a precisely localized increased production of ROS is necessary. ROS work as crucial signalling molecules and participate in many processes resulting in invadopodia formation. ROS in tumour cells are produced by specific extra-mitochondrial NADPH oxidases (Nox). Several regulatory molecules participating in activation and localization of Nox to invadopodia have been discovered recently (Tks organizer proteins). Furthermore, a regulatory role of Src kinase in ROS production and subsequent invadopodia formation was confirmed. Key words: ECM degradation, invadopodia, invasion, proteases, Nox, ROS, Src kinase, Tks proteins
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Assistance to Victims of Crimes
Hanušová, Kristýna ; Mulák, Jiří (referee)
1 Assistance to victims of Crimes Abstract This thesis is focused on the assistance to victims of crimes. It examines the topic especially on the legal level, from various points of view. It deals with the assistance to victims in terms of legislation, mainly domestic, but also foreign, then it examines the application of legislation in practice and further it analyzes the findings while including suggestions for possible improvement. The goal of this thesis is to evaluate the Victims of Crime Act, whether its written form or its application in practice and to propose possible amendments in order to improve the role of the victim, which is after all an unwritten purpose of the Victims of Crime Act. This thesis is divided to an introduction, five separate chapters and a conclusion. In its first chapter, the thesis is focused on the person of the victim, purely from the point of view of the legislation. It defines direct and indirect victim, as well as particularly vulnerable victim. Finally it describes differences between a victim and an injured party. The second chapter represents a key part of the thesis since it is focused on the Victims of Crime Act itself and the rights arising out of it for victims. Step by step the chapter analyzes the right to professional assistance, right to information, right to...
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Assistance to victims of Crimes
Hanušová, Kristýna ; Pelc, Vladimír (advisor) ; Hořák, Jaromír (referee)
1 Assistance to victims of Crimes Abstract This thesis is focused on the assistance to victims of crimes. It examines the topic especially on the legal level, from various points of view. It deals with the assistance to victims in terms of legislation, mainly domestic, but also foreign, then it examines the application of legislation in practice and further it analyzes the findings while including suggestions for possible improvement. The goal of this thesis is to evaluate the Victims of Crime Act, whether its written form or its application in practice and to propose possible amendments in order to improve the role of the victim, which is after all an unwritten purpose of the Victims of Crime Act. This thesis is divided to an introduction, five separate chapters and a conclusion. In its first chapter, the thesis is focused on the person of the victim, purely from the point of view of the legislation. It defines direct and indirect victim, as well as particularly vulnerable victim. Finally it describes differences between a victim and an injured party. The second chapter represents a key part of the thesis since it is focused on the Victims of Crime Act itself and the rights arising out of it for victims. Step by step the chapter analyzes the right to professional assistance, right to information, right to...
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Italian refugees in the surroundings of Sušice during the First World War
GRUBHOFFER HANUSOVÁ, Kristýna
This thesis deals with the Italian refugees in the surroundings of Sušice during the First World War. The first chapter summarizes the problem of the First World War in the Czech and the Italian historiography. What follows is the introduction of the problem of the Italian refugees and the perception of this phenomenon again by the Czech and the Italian historiography. The second chapter is based on the primary sources research and its aim is to map the sojourn of the Italian refugees in the region of Sušice in 19151919.
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The role of NADPH oxidase and ros in invadopodia formation
Hanušová, Kristýna ; Vrbacký, Marek (referee) ; Brábek, Jan (advisor)
Invadopodia as specific organelles enabling tumour cells movement, spreading over the organism and ultimately formation of metastasis are possible and promising targets of tumour therapy. Recently, many interesting facts about assembly and mechanism of function of invadopodia were discovered. Invadopodia are centres of ECM degradation by extra-cellular proteases facilitating an invasion of tumour cells. For creation of invadopodia a precisely localized increased production of ROS is necessary. ROS work as crucial signalling molecules and participate in many processes resulting in invadopodia formation. ROS in tumour cells are produced by specific extra-mitochondrial NADPH oxidases (Nox). Several regulatory molecules participating in activation and localization of Nox to invadopodia have been discovered recently (Tks organizer proteins). Furthermore, a regulatory role of Src kinase in ROS production and subsequent invadopodia formation was confirmed. Key words: ECM degradation, invadopodia, invasion, proteases, Nox, ROS, Src kinase, Tks proteins
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