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National Repository of Grey Literature

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Function of systemic right ventricle after atrial correction of transposition of great arteries - longitudinal follow-up and impact on exercise capacity Frank Antonová, Petra ; Rohn, Vilém (advisor) ; Linhartová, Kateřina (referee) ; Pudil, Radek (referee) Function of systemic right ventricle after atrial correction of transposition of great arteries - longitudinal follow-up and impact on exercise capacity Abstract Maximal oxygen uptake during cardiopulmonary exercise test determines decision about pregnancy, therapeutic measures and timing of surgery and heart transplantation. Atrial correction of transposition of great arteries places right ventricle in the systemic positon. The aim of our work was to assess relation of parameters of function of systemic right ventricle to maximal oxygen uptake. 86 patients after Senning correction were subjected to testing of NYHA class, blood tests of NT-proBNP, Holter monitoring and cardiopulmonary exercise test. Systolic function of right ventricle was assessed semiquantitatively by echocardiography and precisely calculated by heart MRI. Maximal oxygen uptake was not associated with NYHA, NT-proBNP nor systolic function of systemic right and subpulmonary left ventricles. The only parameter associated with VO2max was heart rate reserve. Systolic function of the systemic right ventricle is likely only one integral part of a more complex haemodynamic mechanism of total heart output and its increase during exercise. In the second part of our study we aimed to ascertain long term mortality of all patients after atrial... Detailed record

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