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Risk factors of cardiovascular disease after renal transplantation
 Francová, Lidmila ; Marečková, Olga (advisor)
Risk factors of cardiovascular disease after renal transplantation This study which explores conventional and new markers of cardiovascular diseases after a renal transplantation. We have paid main attention to new markers such as PAPP-A (pregnancy-associated plasma protein-A), AGEs (Advanced Glycation End Products) and matrix metalloproteinases (MMP-2 and MMP-9). All of them are involved in the pathogenesis of atherosclerosis and the plaque destabilization. The serum levels of new markers were measured by an enzyme-like immunosorbent assay. The renal function is determined as inulin clearance in ml/s/1.73 m.We have used Excel and MedCal programs for the evaluation of the statistic data. New markers were evaluated by t-test. We have used 21 healthy controls. We have had 142 patients, who have undergone renal transplantation within a period of one year between April 2007 and April 2008. The most numerous age was 60-70 years (31%), follows 50-60 years (28%). From 142 patients there were 98 men (96%) and 44 women (31%). At the time of the study 25% of the patients were smokers, 49% of them never smoke and 26% stopped smoking. The normal body mass index was found out in 39% of the patients, 58% was overweight . The average time of dialysis was 12-18 months. Only 8% of the patients had a basal diagnosis made by...
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See also: similar author names
3 Francová, Lenka
5 Francová, Lucie
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