|
|
Je centrální signalizace ghrelinem nezbytná pro odměnu ("reward") navozenou látkami vyvolávajícími závislost?
Urbanová, Daniela ; Hrdina, Radomír (advisor) ; Egecioglu, Emil (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Daniela Urbanová Supervisors: Dr. Elisabet Jerlhag Holm, Ph.D., associate professor Prof. MUDr. Radomír Hrdina, CSc. Title of diploma thesis: Is central ghrelin signalling required for reward induced by addictive drugs? Ghrelin increases food intake and appetite, given centrally as well as peripherally. Plasma levels of ghrelin are increased before meals and decreased after meals. It stimulates appetite by acting on the hypothalamic arcuate nucleus. Ghrelin is mainly produced in stomach. This peptide hormone activates the reward system, suggesting that ghrelin may increase the incentive value of motivated behaviours such as food seeking. The central ghrelin signaling system increases natural reward by consumption of food, as well as by using addictive drugs, such as alcohol and also by sucrose. The mechanism of ghrelin how to activate the reward system involves cholinergic and glutamatergic mechanism. Several other neurotransmitter systems, including GABA, NPY and endocannabinoids, regulate the activity of the reward system and therefore the possible ability of ghrelin to activate the reward systems. This was investigated in the present study. The aim of the present study was to...
|
|
|
Je centrální signalizace ghrelinem nezbytná pro odměnu ("reward") navozenou látkami vyvolávajícími závislost?
Urbanová, Daniela ; Hrdina, Radomír (advisor) ; Egecioglu, Emil (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Daniela Urbanová Supervisors: Dr. Elisabet Jerlhag Holm, Ph.D., associate professor Prof. MUDr. Radomír Hrdina, CSc. Title of diploma thesis: Is central ghrelin signalling required for reward induced by addictive drugs? Ghrelin increases food intake and appetite, given centrally as well as peripherally. Plasma levels of ghrelin are increased before meals and decreased after meals. It stimulates appetite by acting on the hypothalamic arcuate nucleus. Ghrelin is mainly produced in stomach. This peptide hormone activates the reward system, suggesting that ghrelin may increase the incentive value of motivated behaviours such as food seeking. The central ghrelin signaling system increases natural reward by consumption of food, as well as by using addictive drugs, such as alcohol and also by sucrose. The mechanism of ghrelin how to activate the reward system involves cholinergic and glutamatergic mechanism. Several other neurotransmitter systems, including GABA, NPY and endocannabinoids, regulate the activity of the reward system and therefore the possible ability of ghrelin to activate the reward systems. This was investigated in the present study. The aim of the present study was to...
|
guest ::
