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Evaluation of pilot project examination of thyroid gland function in group of pregnant women
 Drncová, Jana ; Límanová, Zdeňka (referee) ; Springer, Drahomíra (advisor)
In 2009 took place in selected regions of the Czech Republic pilot project examination of thyroid gland function, through which was tested the proposed scheme of screening of pregnant women. In terms of screening for congenital defects were women in the 1st trimester of pregnancy investigated with the informed consent on TSH, FT4 and anti-TPO in serum. In the case of positive result, woman has been informed immediately and she was undertaken in care of endocrinologist. The project involved 13 pre-selected laboratories. To determine the analyte were used immunoassay methods which differed in individual laboratories and so were also used different reference intervals too. In frame of the project was examined a group of 2843 women with an average age of 29,4 years. In total were captured 19,6% women with a positive finding. From the whole investigated group had elevated TSH 235 women (8.5%), of whom had reduced FT4 34. Reduced level of TSH had 96 females (3.5%), of whom had a slightly elevated FT4 14 women. Elevated anti-TPO had 9% of women. The outcome of the project showed what is the willingness for cooperation between gynecologists and laboratories and where are the weaknesses of the project. It was verified the economic aspects of screening and also was confirmed relatively large number of women who...
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