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Principles and Methods of social work with Social Groups in training housing regarding to Method of Sanation of Family in social Exclusion.
Doležal, Martin ; Vorlová, Marie (advisor) ; Poláčková, Iva (referee)
This Bachelor work is focused on principals and methods of social work in the higher type of asylum accommodation, which is called House of Training Accommodation. I want to introduce new model of social accommodation and social work for 21. century, with all social classes and groups. This new type of asylum accommodation is serving like an instrument of sanation of family and other pathological appearances in the society, for example unemployment, drug addiction and prevention of heavy crime, homeless and insufficient finantial situation for living, insolvency, rasial discrimination and defense of those clients who are in senior old age with pension income. This work will be focused on concrete objects of social work in the training house: with leaver of creches, applicants to senior homes, 5 clients coming from regime of serving a sentence (VTOS), single mothers with their children or women under domestic and elderly abuse and violence, ethnical minorities and famillies. At the end of this written bachelor work I wish to show compatibility of this type of social work with standards of quality of social work, especially with standards no. 3. and 5., which are the main pillars for the success of social work in the higher asylum accommodation. One chapter also shows problematic point of issue of social work...
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Structure-Antifungal Activity Relationships in Substituted Butenolides
Šenel, Petr ; Pour, Milan (advisor) ; Hampl, František (referee) ; Doležal, Martin (referee)
Within the framework of this Thesis, several series of 3-(4-bromophenyl)-2,5- -dihydrofuran-2-ones with various substituents at C(5) derived from in vitro antifungally active 3-(4-bromophenyl)-5-acetyloxymethyl-2,5-dihydrofuran-2-one were prepared with the aim of further development of potential antifungals based on this lead. Primarily, we focused on the synthesis of furanones bearing alkylidene or alkoxymethyl/aryloxymethyl moiety in position 5. We found that 5-acyloxymethyl and 5-aryloxymethyl furanone derivatives undergo elimination leading to 3-(4-bromophenyl)-5-methylene-2,5-dihydrofuran-2-one under the antifungal screening conditions. This compound initiates fungal cell membrane disruption and is responsible for the antifungal activity of the former. The 5-alkoxymethyl analogues are unable to undergo the elimination process and are therefore inactive. The antifungal activity of 5- alkylidene furanones depends on the substitution of alkylidene side chain. Some of the target compounds displayed interesting cytostatic activities against HeLa S3 and CCRF-CEM cells (IC50 < 5 µmol.L-1 ). Furthermore, syntheses of 4-substituted or 4,5-disubstituted-3-(4-bromophenyl)-2,5- -dihydrofuran-2-ones were carried out. Some of the prepared derivatives possessed notable antifungal or antimicrobial activity.
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Derivatives of pyrazine as potential antituberculotics
Osička, Zdeněk ; Doležal, Martin (advisor) ; Kučerová, Marta (referee)
Mgr. Zdeněk Osička: Pyrazine Derivatives as potential antituberculous drugs I have focused on the synthesis of compounds from the class amides of substituted pyrazinoic acid in my Pharmacy Doctor Thesis. Series of compounds were prepared by the reaction of pyrazinoic acid chloride with corresponding amines. Synthesis underwent in two steps. Final compounds were characterized by the melting point, TLC, elementary analysis, 1H a 13C NMR and IR. All compounds were liable in vitro testing on their biological activity - antimycobacterial, antifungal and antibacterial. In the group of antituberculosis testing the activity grew up from the least to the most lipophility compound.
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Synthesis and comparison of activity of potential reactivators of acetylcholinesterase inhibited by cyclosarine
Lipka, Lukáš ; Doležal, Martin (advisor) ; Kučerová, Marta (referee)
SYNTHESIS OF POTENCIAL QUATERNARY ACETYLCHOLINESTERASE REACTIVATORS AND EVALUATION OF THEIR POTENCY TO REACTIVATE CYCLOSARIN-INHIBITED AChE Mgr. Lukáš Lipka Department of pharmaceutical chemistry and drug control, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic Abstract of the rigorous thesis: Nine potential AChE reactivators were synthesized. Their potency to reactivate AChE inhibited by cyclosarin nerve agent was tested in vitro. According to the obtained results, 1,4- bis(2-hydroxyiminomethylpyridinium)butane dibromide seems to be most potent AChE reactivator. The reactivation potency of these compounds depends on structural factors such as presence of quaternary nitrogens, lenght of the linking chain between both pyridinium rings, and position of the oxime moiety at the pyridinium ring. The independence of potency of reactivator trimedoxim at the kind of anion present in his molecule was validate.
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Azaphthalocyanines as new structural group of fluorescence quencher.
Kopecký, Kamil ; Doležal, Martin (advisor) ; Lang, Kamil (referee) ; Pour, Milan (referee)
1 SUMMARY This dissertation thesis deals with searching of structurally new non-fluorescent quenchers of fluorescence, which may be used for preparation of molecular probes. These potential quenchers are derived from asymmetrically substituted alkylaminoderivatives of tetrapyrazinoporphyrazines - azaphthalocyanines. As the part of this work is preparation of precursors - 5,6-disubstituted pyrazine-2,3-dicarbonitriles. They are starting material for the preparation of final substances - tetrapyrazinoporphyrazines bearing different functional moieties. In total were prepared: 14 intermediates (3 of them have been described in our department) 13 final tetrapyrazinoporphyrazines (1 of them has been described in our department) 1 modified solid phase suitable for synthesis of marked oligonucleotides 2 by-products 23 undescribed compounds were prepared. Synthesis of 4 substances was not successful. Final products were tested for their singlet oxygen quantum yields, stability in solutions used for synthesis of oligonucleotides and subsequently ability of quenching of commercially available fluorofor Cy5® . This ability was compared with commercially available quencher Black Hole Quencher-2® . As a part of this work is confirmation of distribution of congeners arising during the statistical tetramerization of...
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Pregnancy and profession of a nurse
Rusnáková, Marcela ; Tomová, Šárka (advisor) ; Doležal, Martin (referee)
The thesis discusses tbe attitude of nurses and women, without medical education, to pregnancy and childbirths on tbe bases of questionnaires which were distributed to women who were already pregnant or women who are nowadays pregnant. The thesis is divided into two parts - the theoretical and tbe empirical one. Tbe theoretical part re1ates to pregnancy and its physiological process, eating during pregnancy, prenamI care and possibilities of giving birth in the Czech Republic. Trus part is also about the nurse profession and above aH it is about risks taking at work. Tbe second empirical part relates to analysis of questionnaires results. The fmal assessment of the thesis includes appendices. Powered by TCPDF (www.tcpdf.org)
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