|
|
Zhodnocení léčby parodontálních kostních defektů kompozitním syntetickým materiálem Fortoss? Vital
Sukumar, Sujith ; Dřízhal, Ivo (advisor) ; Poleník, Pavel (referee) ; Korábek, Ladislav (referee)
Background Alloplastic bone graft materials are widely been used these days in combination with barrier membranes to achieve guided tissue regeneration in the treatment of periodontal intrabony defects. This study was designed evaluate the clinical outcome of a composite material, beta tricalcium phosphate in combination with calcium sulphate, in the treatment of periodontal intra-bony defects. The combination of these materials is believed to aid in guided tissue regeneration owing to their properties. Methods Forty seven intrabony defects in 26 periodontitis patients were treated with Fortoss® Vital (Biocomposites, Staffordshire, UK). The patients were followed-up for 2 years. Clinical parameters were evaluated which included changes in probing depth (PD), clinical attachment level/loss (CAL) and gingival recession (GR), presence/absence of plaque and bleeding on probing (BOP) at baseline and at one and two years postoperatively. Results A decrease in probing depths (PD) and a gain in clinical attachment level (CAL) were noticed in at one and two years postoperatively. The mean differences in measurements between the baseline and one year postoperatively are a reduction of 1.97 ± 1.15 mm (p < 0.0001) in case of PD, a gain of 1.68 ± 1.12 mm (p < 0.0001) in CAL and an increase of 0.30 ± 0.71 mm (p...
|
|
|
Glycobiology of the head and neck cancer
Valach, Jaroslav ; Smetana, Karel (advisor) ; Dřízhal, Ivo (referee) ; Říhová, Blanka (referee)
iii Abstract Glycobiology represents a very progressive subject of cell biology. Protein-saccharide interactions play not only supporting and cell organization role, but they also represent medium for information storage and its decoding. Galectins, group of animal lectins (saccharide-binding proteins), which have selective affinity to ß-galactosides, are multifactorial molecules. They participate in cell-cell and cell-matrix interaction, transmembrane signaling, apoptosis, pre- mRNA splicing and are also present in various types of carcinomas. High expression of galectin-1 has been detected in cancer stroma originated from squamous cell epithelium. In the previous study we established that the fibroblasts - myofibroblasts transition, apart from the known TGF- beta, is also induced by galectin-1. We compared relationship between galectin-1 expression, presence of myofibroblasts and gene expression in tissue samples from patients with head and neck squamous cell carcinoma. Cancer stroma with myofibroblasts was rich in galectin-1 expression in comparison with stroma without myofibroblasts. Moreover, we used microarray analysis (ILLUMINA) to compare the whole genome transcriptome from samples with and without presence of galectin-1. High expression of galectin-1 in tissue samples corresponded with expression...
|
|
|
Glycobiology of the head and neck cancer
Valach, Jaroslav ; Smetana, Karel (advisor) ; Dřízhal, Ivo (referee) ; Říhová, Blanka (referee)
iii Abstract Glycobiology represents a very progressive subject of cell biology. Protein-saccharide interactions play not only supporting and cell organization role, but they also represent medium for information storage and its decoding. Galectins, group of animal lectins (saccharide-binding proteins), which have selective affinity to ß-galactosides, are multifactorial molecules. They participate in cell-cell and cell-matrix interaction, transmembrane signaling, apoptosis, pre- mRNA splicing and are also present in various types of carcinomas. High expression of galectin-1 has been detected in cancer stroma originated from squamous cell epithelium. In the previous study we established that the fibroblasts - myofibroblasts transition, apart from the known TGF- beta, is also induced by galectin-1. We compared relationship between galectin-1 expression, presence of myofibroblasts and gene expression in tissue samples from patients with head and neck squamous cell carcinoma. Cancer stroma with myofibroblasts was rich in galectin-1 expression in comparison with stroma without myofibroblasts. Moreover, we used microarray analysis (ILLUMINA) to compare the whole genome transcriptome from samples with and without presence of galectin-1. High expression of galectin-1 in tissue samples corresponded with expression...
|
|
|
Zhodnocení léčby parodontálních kostních defektů kompozitním syntetickým materiálem Fortoss? Vital
Sukumar, Sujith ; Dřízhal, Ivo (advisor) ; Poleník, Pavel (referee) ; Korábek, Ladislav (referee)
Background Alloplastic bone graft materials are widely been used these days in combination with barrier membranes to achieve guided tissue regeneration in the treatment of periodontal intrabony defects. This study was designed evaluate the clinical outcome of a composite material, beta tricalcium phosphate in combination with calcium sulphate, in the treatment of periodontal intra-bony defects. The combination of these materials is believed to aid in guided tissue regeneration owing to their properties. Methods Forty seven intrabony defects in 26 periodontitis patients were treated with Fortoss® Vital (Biocomposites, Staffordshire, UK). The patients were followed-up for 2 years. Clinical parameters were evaluated which included changes in probing depth (PD), clinical attachment level/loss (CAL) and gingival recession (GR), presence/absence of plaque and bleeding on probing (BOP) at baseline and at one and two years postoperatively. Results A decrease in probing depths (PD) and a gain in clinical attachment level (CAL) were noticed in at one and two years postoperatively. The mean differences in measurements between the baseline and one year postoperatively are a reduction of 1.97 ± 1.15 mm (p < 0.0001) in case of PD, a gain of 1.68 ± 1.12 mm (p < 0.0001) in CAL and an increase of 0.30 ± 0.71 mm (p...
|
|
| |
|
| |
|
| |
guest ::
