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Isolation and semi-synthesis of germacranolide derivatives: onopordopicrin
 Cejnarová, Eliška ; Karabanovich, Galina (advisor) ; Roh, Jaroslav (referee)
University of Salamanca Faculty of Pharmacy Department of Pharmaceutical Science: Pharmaceutical Chemistry Student: Eliška Cejnarová Supervisor: prof. Esther del Olmo Title of thesis: Isolation and semi-synthesis of germacranolide derivatives: onopordopicrin This work is focused on onopordopicrin (ONO) as a potent molecule with antiprotozoal activity. ONO is a sesquiterpene lactone of germacranolide structure. Sesquiterpene lactones are typical secondary metabolites of family Asteraceae. As a source of ONO Centaurea ornata Willd. (Asteraceae) was used. It is a thistle-like endemic plant of the Iberian Peninsula. The plant was collected in July 2022, in Zamora region. First, an ether extract from the aerial flowering part of the plant was obtained (0.26 % of the dried plant weight). The crude plant extract was dissolved in methanolic solution and fractionated by liquid/liquid separation with hexane. Then the methanolic part was concentrated, dissolved in water and fractionated with solvents of increasing polarity (chloroform, ethyl acetate and n-butanol). The chloroform fraction containing ONO was purified by column chromatography to obtain the major compound ONO, which represented 54.8 % of crude extract. Figure 1. Modifications of onopordopicrin The aim of this work was the synthesis of novel...
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