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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
The effect of enriched blood plasma on the treatment of chronic wounds
 Šíma, Petr ; Džupa, Valér (advisor) ; Rob, Filip (referee) ; Burda, Rastislav (referee)
Population ageing is connected with increased incidence of chronic diseases. Some of the frequent conditions are chronic skin defects which are not life threatening, however, they significantly impair the quality of patient's life. The aim of this study is to present and test new materials and procedures leading to improvement and acceleration of treatment of lower leg ulcers. The first part of the study is focused on experimental laboratory testing of the impact of platelet rich plasma on cell growth in the in-vitro conditions. The experiment comprised of combination of new materials made from nanofibers generated from various types of organic polymers. Bio-compatibility and bio-degradability of cell carriers intended for treatment of chronic defects and mechanical properties of materials were monitored. The second part of the study is focused on the proof of better healing of chronic defects if the platelet rich plasma is used locally. The cohort included 25 patients with chronic defects who were treated using the autologous growth factors applied on nanocarriers. The control group included 15 patients treated by a standard moist wound therapy. The surface area and depth of the defect was measured and the results were subsequently statistically processed and evaluated. The third part of the...
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