National Repository of Grey Literature 5 records found  Search took 0.01 seconds. 
The quantitative exploration of refractory period in human atrial cells
Brožková, K. ; Pásek, Michal ; Šlichta, J.
The refractory period of cardiac cell plays a significant role in process of suppression of cardiac arrhythmias. The aim of this study is to explore the refractory period of human atrial cells. The method used in this work is based on quantitative modelling.
Computational model of cardiac cell contraction
Šlichta, J. ; Pásek, Michal ; Brožková, K.
Předmětem příspěvku je návrh modelu kontrakce srdečních buněk. Model popisuje procesy vedoucí k interakci kontraktilních bílkovin aktinu a myozinu a je pokračováním práce jejíž cílem je sestavení celkového modelu vazby excitace-kontrakce.
The simulation of effect of membrane channel block by propafenone on electrical activity on human atrial cells
Brožková, K. ; Pásek, Michal ; Šlichta, J.
The main aim of this study is to explore the effect of propafenone on suppression of irregular excitations in human atrial cell. A program was designed that contains the computational model of electric activity on human atrial cells and the mathematical model of interaction of propafenone with INa-channels. This integrated model can served for simulations of the drug effects.
Computer modelling of origin of arrhythmias in myocardial cell
Brožková, K. ; Pásek, Michal
This contribution presents the effect of changes of membrane channel conductivity on the origin of arrhythmias in cardiac cells. The simulations were performed for stimulation frequency 2Hz and compared with results for stimulation frequency 1Hz. It was confirmed that the increase of conductivity of ICa-channels and decrease of conductivity of IK1, INaCa and INaK channels induce single cell arrhythmias.

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2 Brožková, Kristýna
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