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A study of biodegradable polyesters based nanoparticles properties
Blažková, Jiřina ; Holas, Ondřej (advisor) ; Dittrich, Milan (referee)
10 ABSTRACT Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Consultant: PharmDr. Ondřej Holas, PhD. Student: Jiřina Blažková Title of thesis: A study of biodegradable polyesters based nanoparticles properties Nanoparticles (NPs) are particles with a diameter size ranging between 1 - 500 nm. They are preferably used as drug delivery systems or imaging systems. NPs are able to encapsulate both hydrophilic and hydrophobic drugs and also macromolecules such as peptides or mRNAs. The aim of this study was to specify selected properties of NPs prepared from poly (lactide-co-glycolide) polymer (PLGA) using polyvinyl alcohol as a surfactant. Nanoprecipitation was chosen as a preparation method. NPs were prepared from a branched PLGA copolymer and from a conventional linear PLGA polymer/oligomer. The main task was a stability study. The effect of the pH and the type of the used polymer of the nanoparticle suspension on the morphology of the nanoparticles was evaluated over one month period. The following parameters of nanoparticles with two model drugs (curcumin and procaine) were also monitored: encapsulation efficiency, drug loading and recovery yield. Dissolution tests were performer and the suitability of individual polymers for different types of drugs...
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A study of biodegradable polyesters based nanoparticles properties
Blažková, Jiřina ; Holas, Ondřej (advisor) ; Dittrich, Milan (referee)
10 ABSTRACT Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Consultant: PharmDr. Ondřej Holas, PhD. Student: Jiřina Blažková Title of thesis: A study of biodegradable polyesters based nanoparticles properties Nanoparticles (NPs) are particles with a diameter size ranging between 1 - 500 nm. They are preferably used as drug delivery systems or imaging systems. NPs are able to encapsulate both hydrophilic and hydrophobic drugs and also macromolecules such as peptides or mRNAs. The aim of this study was to specify selected properties of NPs prepared from poly (lactide-co-glycolide) polymer (PLGA) using polyvinyl alcohol as a surfactant. Nanoprecipitation was chosen as a preparation method. NPs were prepared from a branched PLGA copolymer and from a conventional linear PLGA polymer/oligomer. The main task was a stability study. The effect of the pH and the type of the used polymer of the nanoparticle suspension on the morphology of the nanoparticles was evaluated over one month period. The following parameters of nanoparticles with two model drugs (curcumin and procaine) were also monitored: encapsulation efficiency, drug loading and recovery yield. Dissolution tests were performer and the suitability of individual polymers for different types of drugs...
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Migration politics of Australia: shift or continuity in this policy?
Blažková, Jiřina ; Cihelková, Eva (advisor) ; Popovová, Marie (referee)
The primary goal of this paper is to analyse the development of Australian migration politics from its creation to the present. By fundamentally examining the migration legislation and the structure of Department of Immigration and Citizenship, this paper analyses global migration flow in comparison to Australia. After dissecting the influential periods in Australian immigration from the: gold rush; White Australia; and, multicultural eras of Australian immigration, this paper charts the creation and examines the development of Australian immigration policy. This document then draws attention to the contemporary immigration policy and migration flows in Australia. Highlighted at the end is the correlation between: population and economic growth with immigrant intake and, Australian political changes at the beginning of the 21st century.
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