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Evaluation of viscoelastic parameters of co-processed materials and their components
Balušíková, Nikola ; Svačinová, Petra (advisor) ; Kováčik, Andrej (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: PharmDr. Petra Svačinová, Ph.D. Student: Nikola Balušíková Title of Thesis: Evaluation of viscoelastic parameters of co-processed materials and their components. Co-processed excipients (CPE) are defined as the combination of two or more substances, which are physically modified by an appropriate manufacturing process (e.g. wet granulation, spray-drying). These types of excipients are currently increasingly used for production of tablets by direct compression technology. Due to the availability of a wide range of initial materials for their production, there is a possibility to obtain large number of combinations with required characteristics and better properties than the simple physical mixtures. Although the composition of CPE may be very similar, the small changes in the component's characteristics can make them behave differently during compression. The thesis is focused on the evaluation of the viscoelastic properties of selected CPE and their components (Cellactose 80, Avicel CE 15, Avicel DG, Avicel HFE 102, MicroceLac 100, Arbocel A 300, Arbocel M 80, Avicel PH1 02, Guar gum, Mannitol, Di-Cafos D 160, Lactochem) using the stress relaxation test at maximal compression force of 5 kN...
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