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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Structural-functional aspects of the Bordetella pertussis adenylate cyclase toxin
 Březinová, Karolína ; Bumba, Ladislav (advisor) ; Brzobohatá, Hana (referee)
Whooping cough (pertussis) is a highly infectious respiratory disease caused by the Gram-negative bacterium Bordetella pertussis. Even though the vaccination rate of the population is high, pertussis is one of the most widespread vaccine-preventable diseases. The bacterium produces a variety of virulence factors that facilitate the process of colonization of the ciliated epithelium and infection of the upper respiratory tract. Among the most important virulence factors is the adenylate cyclase toxin (CyaA). This toxin belongs to the so- called RTX (Repeat-In-ToXins) proteins, which are released from the bacterium using the Type 1 secretion apparatus (T1SS). CyaA is a multifunctional toxin, showing both hemolytic and cytotoxic activity. The cytotoxic activity is caused by the N-terminal adenylyl cyclase (AC) domain, which is translocated across the cytoplasmic membrane into the cell cytosol, where upon interaction with calmodulin catalyzes the uncontrolled conversion of adenosine triphosphate (ATP) to cyclic adenosine-3',5'-monophosphate (cAMP). CyaA is recognized by the integrin receptor CD11b/CD18 (also known as complement receptor type 3), which is primarily found on phagocytic cells of the host organism. This work focuses on the structural- functional aspects of the CyaA toxin and summarizes...
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See also: similar author names
5 BREZINOVÁ, Kateřina
1 Brezinová, Katarína
5 Brezinová, Kateřina
5 BŘEZINOVÁ, Kristýna
5 Březinová, Kateřina
2 Březinová, Kristina
5 Březinová, Kristýna
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