National Repository of Grey Literature 5 records found  Search took 0.00 seconds. 
Teaching First Aid and English Using CLIL Method at Lower Secondary Level
BÍLKOVÁ, Pavla
The diploma thesis deals with teaching first aid and English (CLIL method). The main purpose was to design five CLIL teaching materials for fist aid learning. The first part of the thesis focuses on CLIL method and its principles, first aid and its incorporation to the Framework Educational Program. The second part deals with creation of the teaching materials. Their verification took place at lower secondary level in the ninth grade during three lessons. It was found out that CLIL method did not influence the pupils' knowledge in a negative way, because they reached similar results as pupils who were aught in their mother tongue.
Monitoring of immune parameters during anti-tumor immunotherapy
Bílková, Pavla ; Palich Fučíková, Jitka (advisor) ; Fialová, Anna (referee)
Dendritic cells are the most effective antigen presenting cells in humans, they stimulate naive T lymphocytes and thus initiate specific immune response. The discovery of dendritic cells and understanding of their functions contributed to the idea of usingdendritic cells for the treatment of cancer. Anti tumor immunotherapy is a therapeutic strategy that aims to induce and maintain immune responses against tumor cells. Currently, immunotherapy based on dendritic cells has strong position among other anti cancer therapies and seems to be a promising therapeutic option for patients with tumors. In this work, I evaluated the effectiveness of treatment in patients with prostate cancer treated with immunotherapy based on dendritic cells. I focused on the detection of antigen specific T lymphocytes in peripheral blood against tumor antigens, PSA, NY ESO 1, MAGE A1 and MAGE A3. Using a 3 day standard protocol for the detection of antigen specific T cells using intracellular cytokine staining we were able to detect only a small percentage of this minor population. Only after extension of the protocol, we increased the sensitivity setting and we detected a significantly increased frequency of antigen specific T lymphocytes in the peripheral blood after one year DC vaccines application.
Evaluation of key parameters of the immune system in response to the treatment of active cellular immunotherapy DCVAC/PCa in patients with prostate cancer in II. phase of clinical trial.
Bílková, Pavla ; Palich Fučíková, Jitka (advisor) ; Froňková, Eva (referee)
Prostate cancer is one of the most common types of cancer in men, in developed countries. The treatment options for the advanced and relapsed stage of this disease are very limited. Immunotherapy seems to be a potential new alternative in the treatment of cancer. According to the theory of immune surveillance, the immune system recognizes and eliminates tumor cells by various of mechanisms in the early stages of the disease. Immunotherapy is a treatment method using both innate and adaptive immune mechanisms to activate anti-tumor immunity. Several clinical and preclinical studies of tumour immunotherapy illustrate several promising immunological principles to treat cancer. This is expecially relevant in the case of prostate cancer, as recent approval of sipuleucel-T by the US Food and Drug Administration marks the first antigen-specific immunotherapy approved for cancer treatment. Scientific team at department of Immunology, 2nd Medical school, hospital Motol and biotechnology company SOTIO is developing a next generation Active Cellular Immunotherapy based on activated dendritic cells, focusing on the treatment of prostate cancer. The aim of my thesis was to evaluate the presence of antigen specific immune response induced by immunotherapy by DCVAC/PCa in I./II. phase of clinical trial in two...
Monitoring of immune parameters during anti-tumor immunotherapy
Bílková, Pavla ; Palich Fučíková, Jitka (advisor) ; Fialová, Anna (referee)
Dendritic cells are the most effective antigen presenting cells in humans, they stimulate naive T lymphocytes and thus initiate specific immune response. The discovery of dendritic cells and understanding of their functions contributed to the idea of usingdendritic cells for the treatment of cancer. Anti tumor immunotherapy is a therapeutic strategy that aims to induce and maintain immune responses against tumor cells. Currently, immunotherapy based on dendritic cells has strong position among other anti cancer therapies and seems to be a promising therapeutic option for patients with tumors. In this work, I evaluated the effectiveness of treatment in patients with prostate cancer treated with immunotherapy based on dendritic cells. I focused on the detection of antigen specific T lymphocytes in peripheral blood against tumor antigens, PSA, NY ESO 1, MAGE A1 and MAGE A3. Using a 3 day standard protocol for the detection of antigen specific T cells using intracellular cytokine staining we were able to detect only a small percentage of this minor population. Only after extension of the protocol, we increased the sensitivity setting and we detected a significantly increased frequency of antigen specific T lymphocytes in the peripheral blood after one year DC vaccines application.

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7 BÍLKOVÁ, Pavlína
5 Bílková, Pavla
7 Bílková, Pavlína
9 Bílková, Petra
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