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National Repository of Grey Literature

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Vztah HP1 proteinů k centrometrickému heterochromatinu charakterizovaný přítomností H3(K9) a absencí H3(K4) dimetylace Bártová, Eva ; Harničarová, Andrea ; Pacherník, J. ; Galiová-Šustáčková, Gabriela ; Kozubek, Stanislav In this study we have examined arrangement of HP1 proteins and histone modifications related to the centromeric heterochromatin of human and mouse chromosomes. Focal arrangement of HP1beta was characterized by a smaller foci located closer to the nuclear periphery and larger foci associated with the nucleoli of human cells. Heterochromatin of selected centromeres (9cen,14/22cen,Ycen) co localized with foci of HP1beta. Immuno-FISH analyses revealed that centromeres analyzed were H3(K9) dimethylated and absent of H3(K4) dimethylation. Detailed record

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