National Repository of Grey Literature 5 records found  Search took 0.01 seconds. 
Ruthenium-based nanoparticles and testing of their anticancer activity
Žáková, Eliška ; Fohlerová, Zdenka (referee) ; Heger,, Zbyněk (advisor)
Neoplastic diseases hold the second place of the most common causes of death worldwide. Available treatments include various combinations of surgery, chemotherapy, radiation, hormone therapy, immune therapy and targeted therapy. The emphasis is currently laid on nanomedicine, where new nanosized complexes are developed and applied for the targeted treatment and chemotherapy. The aim is to significantly improve the anticancer effect and decrease the damage to organism. In this thesis, ruthenium nanoparticles with a size of 12–14 nm were synthesized and their surface modified with polyvinylpyrrolidone. Furthermore these were subsequently modified with polyoxyethylene(40)stearate for binding of doxorubicin. These nanoparticles were tested on breast carcinoma cells (MDA-MB-231), ovarian carcinoma cells (A2780) and neuroblastoma cells (UKF-NB-4). Apoptosis and necrosis testing showed 60—64 % increase in apoptosis when comparing ruthenium nanoparticles modified with doxorubicin to nonmodified ruthenium nanoparticles. The modification increased level of oxidative stress in tumorous cells and slightly a genotoxicity to non-tumorous cells, nevertheless the hemocompatibility was significantly improved. Testing has proven with IC50 0.98 g/ml, 3.91 g/ml and 1.95 g/ml higher sensitivity to these cells and confirmed expected anticancer activity. Compared to one of the most common chemotherapeutic agents cisplatin the modified ruthenium nanoparticles are significantly more toxic to cell lines A2780 (IC50=21 µg/ml), MDA-MB-231 (IC50=9 µg/ml) and UKF-NB-4 (IC50=4 µg/ml).
Memorial and memory in the Czech Republic after November 1989
Žáková, Eliška ; Mitášová, Monika (referee) ; Lahoda, Vojtěch (advisor)
This thesis deals with contemporary monumental and memorial production in the Czech Republic and focuses specifically on the theoretical side of the monumental genre. The first part systematically summarizes foreign research outcomes in the examined field, shows some concrete examples from abroad, and reflects the most progressive trends in today's world monumental production. The second part focuses on the Czech background. It is based on the previous theoretical findings and uses three different case studies to illustrate the core aspects of the monumental issue. The case studies deal with the Prague Memorial to the Victims of Communism by Olbram Zoubek, the Liberec Memorial to the Fighters and Fallen for the Country's Freedom by the artistic trio Stolín - Stolín - Mitášová, and the Rožnov Memorial to the Victims of the First and Second World War by Václav Fiala. Exemplary analysis is used for a more detailed description of the social, political, and esthetical context of the creation of the examined memorials, with a special emphasis on their potential to preserve historical memory. The aim of this thesis is to contribute to the creation of a theoretical basis for the contemporary thinking about the monumental genre.
Advertising in the Selected Firm - Tax and Accounting Aspects
Žáková, Eliška ; Lepková, Hana (referee) ; Hanušová, Helena (advisor)
This diploma work analyzes the current marketing and promotional service of BTU Centre of Sports Activities and following accounting and tax issues. It contains propsal of more effective advertising leasing to increased revenue from the profit-making business.
Segmentation of retinal blood vessels in 3D images from optical coherence tomography
Žáková, Eliška ; Odstrčilík, Jan (referee) ; Štohanzlová, Petra (advisor)
The thesis deals with optical coherence tomography theory, eye and retinal structure and possibilities of retinal blood vessel segmentation in OCT scans. Further the segmentation of retinal layers used for blood vessels segmentation by OCTSEG application is shown. In the end 2D projections in the chosen layer of retinal blood vessels by different algorithms using mean, median, minimums and maximums in which are later segmented blood vessels are made and the results are compared. The best detection of blood vessels is in 2D projections made by algorithm using maximums. In the second case was better results of detection including background noise.
Bussines Plan
Žáková, Eliška ; Kostoláni, Rastislav (referee) ; Hanušová, Helena (advisor)
This diploma thesis is focused on creating a business plan for the new project of BTU Centre od Sports Activities. It analyzes the current situation from the view of internal ana external environment. It contains proposal for the realization of the project "Sport for firms and companies" mainly focused on costs and marketing strategy.

See also: similar author names
3 ŽÁKOVÁ, Erika
3 Žáková, Erika
1 Žáková, Eva
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