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The Field-test Results of Verification the Antihelmintic Efficiency of Ivermectin Among
Švecová, Milena ; Lamka, Jiří (advisor) ; Ducháček, Lubomír (referee)
/ ABSTRACT Charles University in Prague Faculty of Pharmacy in Hradec Králové School of Pharmacology and Toxicology Candidate: Mgr. Milena Švecová External counsellor: Prof. RNDr. Jiří Lamka, CSc. Consultant: Doc. MVDr. Karel Bukovjan, CSc. Name of the rigorous work: The field-test results of verification the antihelmintic efficiency of Ivermectin among species of fallow deers This rigourous work is concerned with the usage of the medicine with active substance Ivermectin, so called CERMIX. The usage of medicine was observed while feeding hoofed animals by a premixed form of CERMIX contained in the given feedstuff. From the categorizing into zoological system point of view, the target species and their biological characteristics are being described. The most important medicaments that are being used in hoofed animals breeding and the needed legislation for their usage can be found in synopsis. The core of particular work consists in the observation of Ivermectin efficiency. In other words, comparing the proportion of parasitic infestation among fallow deers at two deer- parks, namely: Volský žlab and Kněžičky. The infection intensity was observed before the Ivermectin usage and twenty-eight days after at these two deer-parks. The research done in years 2005-2010 results in the proved efficiency of...
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The Field-test Results of Verification the Antihelmintic Efficiency of Ivermectin Among
Švecová, Milena ; Lamka, Jiří (advisor) ; Ducháček, Lubomír (referee)
/ ABSTRACT Charles University in Prague Faculty of Pharmacy in Hradec Králové School of Pharmacology and Toxicology Candidate: Mgr. Milena Švecová External counsellor: Prof. RNDr. Jiří Lamka, CSc. Consultant: Doc. MVDr. Karel Bukovjan, CSc. Name of the rigorous work: The field-test results of verification the antihelmintic efficiency of Ivermectin among species of fallow deers This rigourous work is concerned with the usage of the medicine with active substance Ivermectin, so called CERMIX. The usage of medicine was observed while feeding hoofed animals by a premixed form of CERMIX contained in the given feedstuff. From the categorizing into zoological system point of view, the target species and their biological characteristics are being described. The most important medicaments that are being used in hoofed animals breeding and the needed legislation for their usage can be found in synopsis. The core of particular work consists in the observation of Ivermectin efficiency. In other words, comparing the proportion of parasitic infestation among fallow deers at two deer- parks, namely: Volský žlab and Kněžičky. The infection intensity was observed before the Ivermectin usage and twenty-eight days after at these two deer-parks. The research done in years 2005-2010 results in the proved efficiency of...
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Studium molekulárních mechanismů účinku kyseliny nikotinové v léčbě aterosklerózy
Švecová, Milena ; Nachtigal, Petr (referee) ; Štaud, František (advisor)
To investigate molecular mechanism of action of nicotinic acid in the treatment of atherosclerosis, we have used genetically modified mice, LDLR k.o. mice and PumaG double deficient mice. Mice were fed high fat diet for sixteen weeks and treated with or without 0.3% nicotinic acid in drinking water. Afterwards mice were sacrificed and the hearts were used for determination of the atherosclerotic lesions by defining the plaque area and areas immunostained for macrophages. Further we aimed at clearing the mechanism of action of nicotinic acid. By using fluorescence microscopy we found area with expression of gene GPR109A in peritoneal exudates cells. Next, by setting the limit of intracellular calcium I was measuring the response of peritoneal cells to the nicotinic acid with subsequent addition of chemokines - mcp-1, rantes, il- 8, mip-1- α. The goal was to lower the level of chemokines and thus to reduce the inflammation.
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