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Five-phase induction machine
Škoda, Josef ; Vítek, Ondřej (referee) ; Mach, Martin (advisor)
This thesis deals with the design of a five-phase machine. In the first part of this thesis are presented theoretical knowledge about five-phase machines. In the next part of the thesis is designed five-phase machine by analytical calculation according to selected parameters. This calculation includes the resulting load and start characteristics. The geometrical parameters of the machine are transferred to the Ansys program, where the finite element calculation is performed together with the required simulations. The results are compared and commented.
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Bioinformatic aspects of nuclear receptors in pharmacotherapy
Škoda, Josef ; Pávek, Petr (advisor) ; Kollár, Peter (referee) ; Matoušková, Petra (referee)
IN ENGLISH LANGUAGE Candidate: Mgr. Josef Škoda Supervisor: Prof. PharmDr. Petr Pávek, PhD. Title of the doctoral thesis: Bioinformatical aspects of nuclear receptors in pharmacotherapy The liver plays a central role in energy homeostasis via processing post-prandial excess energy into storage molecules and reusing stored energy via gluconeogenesis during the fasting period. This tight energy balance is maintained by a myriad of regulating processes. Dysfunction of metabolic control is a key event of severe diseases in today's population, starting with obesity, insulin resistance, and metabolic syndrome, proceeding to end-stage complications in type 2 diabetes, whole organ malfunctions, or even tumor diseases. Master players in metabolic regulation are nuclear receptors (NR) activated by endogenous stimuli or scavenging for nutritional or toxicological signals. NRs regulate gene transcription activation and therefore maintain liver metabolic plasticity. In this thesis, modern molecular biology approaches were used to study ligands of NRs and the effects of their treatment. After the typical activation of a NR, hundreds of genes are regulated, which is beyond the ability to study with conventional biology methods. For this purpose, omics methods are an ideal solution. They are characterized by...
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Five-phase induction machine
Škoda, Josef ; Vítek, Ondřej (referee) ; Mach, Martin (advisor)
This thesis deals with the design of a five-phase machine. In the first part of this thesis are presented theoretical knowledge about five-phase machines. In the next part of the thesis is designed five-phase machine by analytical calculation according to selected parameters. This calculation includes the resulting load and start characteristics. The geometrical parameters of the machine are transferred to the Ansys program, where the finite element calculation is performed together with the required simulations. The results are compared and commented.
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Synthesis of pyrrole-based inhibitors of the macrophage infectivity potentiator proteins
Škoda, Josef ; Roh, Jaroslav (advisor) ; Špulák, Marcel (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Supervisors: Prof. Dr. Ulrike Holzgrabe PharmDr. Jaroslav Roh, PhD Candidate: Josef Skoda Title of diploma thesis: Synthesis of pyrrole macrophage infectivity potentiator inhibitors Pathogens Burkholderia pseudomallei and Legionella pneumophila cause severe diseases like Legionnaire's disease and melioidosis. While Legionnaire's disease manifests as acute pneumonia, melioidosis has different clinical features and ends by multi-organ involvement and septic shock. Low sensibility of gram negative bacteria B. pseudomallei and L. pneumophila to antibiotics together with threatening resistance represent a great problem. For these pathogens their virulent factor macrophage infectivity potentiator (MIP) protein is a suitable target. MIP proteins are peptidyl/prolyl cis/trans isomerases, highly important factor of penetration and dissemination for B. pseudomallei a L. pneumophila. MIP protein belongs to FK506 binding protein (FKBPs) superfamily, which forms highly stable complex with its inhibitors tacrolimus and rapamycin. Due their immunosuppressive activity, these drugs are contraindicated for treatment of infection diseases. However inhibition of the protein proves that MIP protein is...
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