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Residential Building
Uhlíř, Karel ; Šafařík, Martin (referee) ; Sukopová, Dáša (advisor)
Diploma thesis develops comprehensive documentation of the new building construction of residential house on the level of the implementation of the project construction. Proposal emphasizes layout of linked to ensure the technical design, structural, fire safety, protection against noise, energy saving, safety in use. Work is performed in an electronic format using AutoCAD and Microsoft Word (PDF Creator).
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Entrepreneurial Intention of Business Development
Šafařík, Martin ; Vaněk, Petr (referee) ; Žižlavský, Ondřej (advisor)
The Master's thesis theme is „Entrepreneurial Intention of Business Development“. The main aim of the thesis is to carry out a complex analysis of the problem of current situation in a company AUTOSHOP PAULUS, spol. s r.o. and its environment. Furthermore, based on results of the analysis and on the analysed state of the company, the thesis aims to draft measures leading to development of the company or to strenghtening of its position on the market and to raising its sales. The analysis of the company was based on: analysis of general and field environment, analysis of internal effects, financial analysis and SWOT analysis.
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Residential Building
Uhlíř, Karel ; Šafařík, Martin (referee) ; Sukopová, Dáša (advisor)
Diploma thesis develops comprehensive documentation of the new building construction of residential house on the level of the implementation of the project construction. Proposal emphasizes layout of linked to ensure the technical design, structural, fire safety, protection against noise, energy saving, safety in use. Work is performed in an electronic format using AutoCAD and Microsoft Word (PDF Creator).
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Entrepreneurial Intention of Business Development
Šafařík, Martin ; Vaněk, Petr (referee) ; Žižlavský, Ondřej (advisor)
The Master's thesis theme is „Entrepreneurial Intention of Business Development“. The main aim of the thesis is to carry out a complex analysis of the problem of current situation in a company AUTOSHOP PAULUS, spol. s r.o. and its environment. Furthermore, based on results of the analysis and on the analysed state of the company, the thesis aims to draft measures leading to development of the company or to strenghtening of its position on the market and to raising its sales. The analysis of the company was based on: analysis of general and field environment, analysis of internal effects, financial analysis and SWOT analysis.
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The Transformation of the U.S. Labor Market during the Period 1939-1945
Šafařík, Martin ; Johnson, Zdenka (advisor) ; Tajovský, Ladislav (referee)
This bachelor thesis focuses on the influence of the Second World War on the labor market in the USA. In addition to explaining changes to the labor market as a whole, an emphasis is put on the labor market with regard to specific relevant minorities (namely women, Americans of Japanese descent and Afro-Americans). The main part of each chapter is devoted to sector changes in employment on the supply side of the market. This thesis indicates that the circumstances of the Second World War and the Postwar Era greatly shaped the circumstances of the U.S. labor market during these periods. Employment during this time also demonstrated characteristics of being affected greatly by these significant events. The results of this thesis also indicate that the Second World War in the context of the labor market contributed to breaking certain social barriers connected to the process of employment, which in turn accelerated the social evolution of some groups.
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Reaction of prion protein with quinacrine
Zawada, Zbigniew ; Šafařík, Martin ; Šebestík, Jaroslav ; Stibor, Ivan ; Bouř, Petr
Prion protein is supposed to cause Creutzfeld–Jakob disease, which can be treated in cell culture by quinacrine. In this work we study acridinylation reaction of prion protein. We also investigate this reaction theoretically on simple models and calculate activation energies for a large ensemble of acridine derivatives. Found correlation between the reactivity and geometry can enhance the design of the new acridine compounds, particularly for medical purposes.
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Synthetic scan of C-domain from prion proteins
Šebestík, Jaroslav ; Zawada, Zbigniew ; Šafařík, Martin ; Hlaváček, Jan
Prions are suspected as culprits of several neuropathogenic diseases. A combination of chemical and recombinant syntheses is a powerful tool for studying prion role in pathogenesis of neurodegenerative diseases. Due to the presence of “difficult” sequences in the prion protein molecule, chemical ligation procedure using peptide thioesters as key building blocks is a method of choice. Therefore, a synthetic scan of peptides constituting the mouse prion protein (MoPrP) C-domain 93-231 was carried out. The synthesis on chlorotritylchloride resin was the most promising for most peptides. Only the octadecapeptide MoPrP195-212 could not be synthesized by automated peptide synthesis even using the β-sheet breaking dipeptides. This difficulty was overcome by manual peptide synthesis with careful monitoring of coupling and Fmoc removal.
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