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BETA-GLUCANS: WHAT APPLICATIONS? A GENERAL OVERVIEW
Vannucci, Luca ; Mishra, Rajbardhan ; Lukáč, Pavol ; Tenti, Paolo ; Rajsiglová, Lenka ; Větvička, Václav ; Šíma, Petr
Glucans are polysaccharides derived from various sources (e.g. mushrooms, algae, yeast, barley). They can target immune receptors, like Dectin-1 expressed on dendritic cells - antigen presenting cells. Otherwise, interest is rising for their use not only for modulation of immunity, but also of cholesterol levels, or as possible vaccine adjuvants, nanocarriers and functional food components. We will shortly review some aspects in human and veterinarian applications.
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BETA-GLUCANS: WHAT APPLICATIONS? A GENERAL OVERVIEW
Vannucci, Luca ; Mishra, Rajbardhan ; Lukáč, Pavol ; Tenti, Paolo ; Rajsiglová, Lenka ; Větvička, Václav ; Šíma, Petr
Glucans are polysaccharides derived from various sources (e.g. mushrooms, algae, yeast, barley). They can target immune receptors, like Dectin-1 expressed on dendritic cells - antigen presenting cells. Otherwise, interest is rising for their use not only for modulation of immunity, but also of cholesterol levels, or as possible vaccine adjuvants, nanocarriers and functional food components. We will shortly review some aspects in human and veterinarian applications.
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Zoological Preparation Techniques in School Practice
Odcházelová, Tereza ; Mourek, Jan (referee) ; Šíma, Petr (referee)
This thesis consists of description of chosen methods of permanent macroscopic zoological preparations. I verified successfully all the methods in practice and in case of methodological difficulties I optimized them for use in the school environment. In this work I answered the questions that could come up throughout the preparation process, for example: how to preserve the animal correctly; where to acquire the animal legally; what is the best way to maintain the animal's natural colour; what materials to use for the preparation and so on. According to current approaches I created not only a text based version of the manual of all verified preparation methods, but also an online version in form of a web site. To clarify the methods I included video sequences, photographs and schemes. With this e- learning course a teacher will be able to extend the school collection with his own preparations and also will be able to recognize what significant characteristics to point out. As a part of my work I have done a questionnaire focused on using various types of equipment in biology lectures. I have asked primary school teachers and high school teachers from all regions in the Czech Republic. This questionnaire was sent online and 322 out of 1636 people responded. The answers tell us that teachers...
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Observation of human sperm cell immunogenic properties
Cibulka, Jan ; Ulčová-Gallová, Zdeňka (advisor) ; Fingerová, Helena (referee) ; Madar, Jindřich (referee) ; Šíma, Petr (referee)
The issue of human infertility is becoming increasingly pressing, especially in so- called industrially developed countries. Formally, we can share the infertility attributes between the male and the female partner (as a male and female infertility factor), but the problem finally affects the whole parental couple. Perhaps, due to the complexity of the female reproductive tract, it is estimated that over 40% of the reproductive failure is hidden in one or more of its parts. The "strong point" of the male factor is derived from the pathological sperm count. For the remaining 15 to 20% of causes, whether morphological or functional, cannot be to find either clearly or not at all. We talk about the otherwise unexplained infertility, that can be caused in up to 30% immunologically. Due to broad concept of immunology of reproduction, we have chosen literally as a probe into this issue in all respects unique spermatic cell that represents not only a carrier of genetic information, but also a set of antigenic structures. This cell seems to be perfect for this task, because of its availability to most basic laboratory techniques. We will try to familiarize ourselves with some of the obstacles that may prematurely end its mission, especially with the antibodies against its antigenic structures (ASA -...
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Zoological preparation techniques in school practice
Odcházelová, Tereza ; Mourek, Jan (advisor) ; Šíma, Petr (referee)
This thesis consists of description of chosen methods of permanent macroscopic zoological preparations. I verified successfully all the methods in practice and in case of methodological difficulties I optimized them for use in the school environment. In this work I answered the questions that could come up throughout the preparation process, for example: how to preserve the animal correctly; where to acquire the animal legally; what is the best way to maintain the animal's natural colour; what materials to use for the preparation and so on. According to current approaches I created not only a text based version of the manual of all verified preparation methods, but also an online version in form of a web site. To clarify the methods I included video sequences, photographs and schemes. With this e- learning course a teacher will be able to extend the school collection with his own preparations and also will be able to recognize what significant characteristics to point out. As a part of my work I have done a questionnaire focused on using various types of equipment in biology lectures. I have asked primary school teachers and high school teachers from all regions in the Czech Republic. This questionnaire was sent online and 322 out of 1636 people responded. The answers tell us that teachers...
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The role of LIF gene mutations and the relative distribution of NK cells, NKT and T lymphocytes in follicular fluid and blood of women with different history of infertility
Křížan, Jiří ; Šíma, Petr (advisor) ; Jonáková, Věra (referee) ; Kročová, Zuzana (referee)
Charles University in Prague Faculty of Natural Sciences Summary of Ph.D. thesis The role of LIF gene mutations and the relative distribution of NK cells, NKT and T lymphocytes in follicular fluid and blood of women with different history of infertility Jiří Křížan Prague 2010 1 | P a g e Doctoral degree programs in biomedicine Charles University in Prague and the Academy of Sciences of the Czech Republic Programme: Biomedicine Chairman of the Subject Board: Doc. RNDr. Vladimír Holáň, Dr.Sc. Place of study: Institute of Microbiology, v.v.i., Academy of the Czech Sciences Vídeňská 1083, 142 20 Prague 4 phone: +420 296 442 318 Autor: Mgr. Jiří Křížan Supervisor: RNDr. Petr Šíma, CSc. The dissertation can be found at Dean's Office Faculty of Charles University in Prague 2 | P a g e CONTENTS Contents 2 Summary 3 1. Introduction 5 2. Hypotheses and aims 6 3. Material and methods 7 Material: 7 Methods: 8 4. Results 10 5. Discussion 12 6. Conclusion 15 7. References 16 Bibliography of Autor: 18 1. papers in extenso (thesis background) 18 2. papers in extenso (without regard to thesis) 19 3 | P a g e SUMMARY The aim of the dissertation thesis "The role of LIF gene mutations and the relative distribution of NK cells, NKT, and T lymphocytes in follicular fluid and blood of women with different history of infertility"...
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