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Effect of piracetam on advanced dementia with predominated cardiovascular symptoms
Kovtun, Vladimír ; Ďoubal, Stanislav (advisor) ; Zadák, Zdeněk (referee) ; Mrňa, Boris (referee)
From 2001 to 2004 a retrospective non-invasive clinical trial on the effects off Piracetam was carried out in the nursing home in Česká Kamenice. The effect of Piracetam was observed on 150 patients aged 84,29 ( +- 3,5 years ) who suffered from an advanced form of vascular dementia. The patients were diagnosed in accordance with all currently valid criteria. At the time of the clinical trial the patients had been suffering from the disease for more than 6 months. A placebo was administered to the reference group composed of patients suffering from the same disease. The clinical trial lasted for a period of 12 months . The treatment with Piracetam did not demonstrate any positive effects which would be statistically substantial. This is probably due to an increased number of advanced forms of dementia syndrome with an irreversible loss of the brain's ability to compensate. For the above mentioned reasons an early diagnosis of demetia is of high importance because of a possibility to positively influence the disease. We assume that it is a task of an immense significance which goes beyond the boarders of the Czech Republic. Also, it raises the importance of geriatrics and gerontopharmacy on the societal ladder. Obviously, it is necessary to conduct further and much more extensive studies, which would...
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Effect of pentoxifyllin on advanced dementia with predominated cardiovascular symptoms
Mészárosová, Jitka ; Ďoubal, Stanislav (advisor) ; Náhlovský, Jiří (referee) ; Mrňa, Boris (referee)
The high consumption of Pentoxifyllin in patients suffering from vascular dementia led to a concern and a clinical trial conducted in the nursing home in Česká Kamenice from 2001 to 2004. The retrospective survey was carried out on 176 patients and lasted 12 months. If we consider the currently valid criteria for the diagnosis of vascular dementia, the patients showed an advanced form of the disease. The experiment did not demonstrate any positive influence of treatment on either cardiovascular diseases or the mortality of afflicted patients. Despite the fact that we could expect the medicament to have a favourable influence on the symptoms of the advanced form of vascular dementia it was not proven so. It is absolutely essential for doctors to have good background knowledge of diseases and all kinds of particularities accompanying old age, especially when it comes to the early detection of dementia. High consumption of Pentoxifyllin led to a number of experiments and studies trying to prove its efficiency and hence justify prescripcions for the drug. An extended study carried out in 1996 demonstrated the favourable effects of Pentoxifyllin. Our experiment has also showed signs of improvement in pateints with weaker forms of dementia. Final decision on the suitability of the treatment with...
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Biomechanics of veins and vein's substitutes
Stošek, Zdeněk ; Ďoubal, Stanislav (advisor) ; Klemera, Petr (referee)
Mechanical properties of vessel walls influence many physiological functions of organisms and its health status. Biomechanical changes in mechanical properties of vessels accompany process of aging. Consequently, biomechanical characteristics may be marker of aging. Aim of this work was identification of biomechanical characteristics of pig aorta walls on the basis of measurement of impulse and transient mechanical responses of deformation on stress. Work also analyzed linearity of parameters. Measurements were performed by instruments developed on department of biophysics and physical chemistry.
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Measurement of bone density and its use for determination of biological age, prevention and indication of osteoporosis
Krátká, Jitka ; Ďoubal, Stanislav (advisor) ; Klemera, Petr (referee) ; Hála, Tomáš (referee)
The actual level of factual individual ageing of organism is characterized by biological age. By means of measuring function ability of physiological systems it is possible to evaluate the biological age and use it as an indicator of premature ageing and therefore as an indicator of the risk of getting ill. This study brings an overview of contemporary used, non-standard markers for the measurement of biological age and uncovers the possibility of measurement of biological age (BA) of skeleton and its use in osteoporosis precaution. Inclusion of BA measurement of skeleton into basic screening should bring another perspective how to measure objectively the changes in organism that correspond with ageing. Key words: biological age, osteoporosis, bone ageing, osteodenzitometry
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