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New markers of liver fibrosis
Skřebská, Lenka ; Čepová, Jana (advisor) ; Průša, Richard (referee)
This material is talking about problems of liver fibrosis. It Is a very fundamental liver's disease which is bringing about a chronic harm of the liver's tissue. An effect of it is a process defect of fibrogenesis and fibrolysis which has to be balanced. A diagnosis of liver fibrosis on time is important for start an efficient therapy. At this time we are getting diagnosis of the liver fibrosis by liver's biopsy which is bringing many risks for patients and it is disadvantageus for them. This situation is running us to search for a new non-invasive methods. It is a lot of calculations they are using a specific and unspecific markers to determine fundamental measures of specific fibrotisation and nonspecific too. A goal of this work it is to get a contrast between a new automatic imunochemicle ELF test which is using specific markers for the liver fibrosis and using calculations APRI and the Hepascore until now. Powered by TCPDF (www.tcpdf.org)
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Biochemical markers of bone metabolism in female patients with posmenopausal osteoporosis
Kováčová, Libuše ; Čepová, Jana (advisor) ; Masopust, Jaroslav (referee)
The content of this bachelor labour is an introduction into the osteoporosis question. The osteoporosis presents a social disease with adverse effects not only for sick patient but also for society and economy. Through the whole life the bone is still renewaled. Owing to the various factors and with the increasing age, the resorption starts to prevail above the new formation of bone. The biochemicals and radiography investigation are used to the determination of a rate of disappearance of bone tissue. The aim of this work was to recapitulate the diagnostics of the osteoporosis by the postmenopausal women. Write down, which medicaments can be used in treatment of osteoporosis and their asset to patiens. In the labour there are described special biochemicals markers predicative about skeletal turn. In conclusion there are three casuistries, well-founded by value of bone markers, demonstrating the payoff from medication in treatment of this disease. Powered by TCPDF (www.tcpdf.org)
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