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Reconstruction of Brankovice Parish
Čermáková, Kateřina ; Rychnovský, Václav (referee) ; Králová, Zuzana (advisor)
This is a reconstruction of the parish in Brankovice. The building has two floors, is partly a basement, attic, unused, false hip roof. The building was built in the Baroque - Classical style around 1773. The facade is horizontally divided by plinth, shams around windows, and by a cordon cornice lisenas vertically between windows. The front is accentuated by protruding buttress. The building consists of mid-section and two side wings, the layout is strictly symmetrical. The central axis of the main entrance to the building, which is linked to the entrance hall. On the second floor, there is a staircase hall in the central part of the building, connected to all rooms, which are further connected to each other. The rooms on the first floor will be used as an apartment for the pastor. The part of solution is reconstruction and extensions of bathrooms and garage. Bearing system of solved object consists of burnt bricks. The extensions is designed as ceramic brick blocks Therm masonry.
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Intermediate filaments in mammalian cell motility
Čermáková, Kateřina ; Libusová, Lenka (advisor) ; Pelantová, Markéta (referee)
Cell migration is crucial for the formation and maintenance of a multicellular mammalian organism, contributing to important processes such as embryonic development, tissue renewal, and immune surveillance. It is a complex phenomenon involving a plethora of processes, including relevant signalization. An impairment of those processes could be projected into innumerable pathological states, from wound healing disruption to tumour metastasis and invasiveness, thus the interest of many researchers has turned toward migration. The migration of mammalian cells is dependent on a cytoskeleton, which is being considerably rearranged in motile cells. This thesis aims to summarise the role of intermediated filaments in cell motility - the less understood cytoskeletal network in this context. Cytoplasmic, as well as nuclear intermediate filaments, due to their unique mechanical properties, affect cell mechanics. They protect against physical stresses (as cells squeeze through confined pores in a complex intercellular microenvironment) and modulate and direct actomyosin-generated forces, which are the main driving force of migration. In addition, they contribute to important migration- involved steps, such as cell polarisation, cell adhesion to surrounding surfaces, cohesion in collective migration, and...
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Preparation and characterization of human cellular cofactors of retroviral integration.
Čermáková, Kateřina ; Maloy Řezáčová, Pavlína (advisor) ; Obšil, Tomáš (referee)
Lens epithelium-derived growth factor/p75 (LEDGF/p75) is a prominent cellular binding partner of Human Immunodeficiency Virus type 1 (HIV-1) integrase. It is a human nuclear protein, which has been implicated in transcriptional regulation and cell survival. The role of LEDGF/p75 in HIV integration is well characterized, the HIV integrase binding domain (IBD) was identified and structural studies, which provide detail information about this interaction, were done. However, very little is known about its physiological function. As a transcriptional co-activator, LEDGF/p75 is implicated not only in HIV replication, but also in human cancer and autoimmunity. Key feature for both, the viral and cellular role of this protein, is its ability to act as a molecular adaptor tethering proteins to the chromatin fiber. Recently, PogZ (Pogo transposable element derived protein with zinc finger domain) was identified and validated as a new cellular interaction partner of LEDGF/p75. It was shown, that their interaction is mediated by IBD of LEDGF/p75 and the C-terminal domain of PogZ. To gain more insight in this interaction, we have initiated structural studies of their complex. Structural information is crucial for understanding the LEDGF/p75 biological role and might help in design of inhibitors selectively blocking...
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Reasons for and legal forms of the restriction of land ownership rights
Čermáková, Kateřina ; Drobník, Jaroslav (advisor) ; Franková, Martina (referee)
1 Abstract Reasons for and legal forms of the restriction of land ownership rights The purpose of my thesis is to analyse the reasons for and the legal forms of the restriction of land ownership rights. Because the land ownership rights relate to both the private law and the public law, this theme is linked with almost all fields of our legal order. The thesis consists of four chapters. Chapter One is introductory and describes the content the paper is about. Chapter Two defines basic terminology used in the thesis: the proprietary rights, the land, the allotment, the real property and the proprietary rights to land. The chapter is subdivided into three parts. Part One describes proprietary right as one of the human right, which is protected by international conventions and the Declaration of basic rights and freedom. Part Two deals with the land specialities - such as the multifunctional character, the indispensableness, the limited extent, the impossibility of multiplication, the impossibility of placing the land elsewhere, the everlasting existence, the impossibility of consumption and the natural, not human origin. This part also explains other related legal concepts. Part Three discusses the land ownership rights and is subdivided into three sections, which provide the knowledge of object, subject and...
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Reasons for and legal forms of the restriction of land ownership rights
Čermáková, Kateřina ; Drobník, Jaroslav (advisor) ; Franková, Martina (referee)
1 Abstract Reasons for and legal forms of the restriction of land ownership rights The purpose of my thesis is to analyse the reasons for and the legal forms of the restriction of land ownership rights. Because the land ownership rights relate to both the private law and the public law, this theme is linked with almost all fields of our legal order. The thesis consists of four chapters. Chapter One is introductory and describes the content the paper is about. Chapter Two defines basic terminology used in the thesis: the proprietary rights, the land, the allotment, the real property and the proprietary rights to land. The chapter is subdivided into three parts. Part One describes proprietary right as one of the human right, which is protected by international conventions and the Declaration of basic rights and freedom. Part Two deals with the land specialities - such as the multifunctional character, the indispensableness, the limited extent, the impossibility of multiplication, the impossibility of placing the land elsewhere, the everlasting existence, the impossibility of consumption and the natural, not human origin. This part also explains other related legal concepts. Part Three discusses the land ownership rights and is subdivided into three sections, which provide the knowledge of object, subject and...
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Preparation and characterization of human cellular cofactors of retroviral integration.
Čermáková, Kateřina ; Maloy Řezáčová, Pavlína (advisor) ; Obšil, Tomáš (referee)
Lens epithelium-derived growth factor/p75 (LEDGF/p75) is a prominent cellular binding partner of Human Immunodeficiency Virus type 1 (HIV-1) integrase. It is a human nuclear protein, which has been implicated in transcriptional regulation and cell survival. The role of LEDGF/p75 in HIV integration is well characterized, the HIV integrase binding domain (IBD) was identified and structural studies, which provide detail information about this interaction, were done. However, very little is known about its physiological function. As a transcriptional co-activator, LEDGF/p75 is implicated not only in HIV replication, but also in human cancer and autoimmunity. Key feature for both, the viral and cellular role of this protein, is its ability to act as a molecular adaptor tethering proteins to the chromatin fiber. Recently, PogZ (Pogo transposable element derived protein with zinc finger domain) was identified and validated as a new cellular interaction partner of LEDGF/p75. It was shown, that their interaction is mediated by IBD of LEDGF/p75 and the C-terminal domain of PogZ. To gain more insight in this interaction, we have initiated structural studies of their complex. Structural information is crucial for understanding the LEDGF/p75 biological role and might help in design of inhibitors selectively blocking...
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