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Adverse reactions after childhood vaccination in the Czech Republic
Kocourková, Aneta ; Dáňová, Jana (advisor) ; Marešová, Vilma (referee) ; Částková, Jitka (referee)
1 ABSTRACT In the Czech Republic a complex study of adverse reactions after vaccination in children has not been presented yet. Even though reporting of serious adverse reactions to the State Institute for Drug Control (SUKL) is mandatory by law, it is seldom performed. Moreover, there is no analysis correlating adverse reactions that occurred at doctors` surgeries with actual reported adverse reactions to SUKL. The main focus of presented work was to analyze and map adverse reactions appearing after vaccinations from the children's vaccination schedule in the Czech Republic. The study was conducted in the form of retrospective-prospective questionnaires concentrating on adverse reactions, their occurrence, character, seriousness, duration and frequency. Furthermore, the questionnaires also focused on socio-demographic data such as gender, age, residency, parents' education, birth weight. Also, the refusal of the compulsory vaccination was assessed. Occurrence of adverse reactions after vaccination in the Czech Republic was analyzed by questionnaires in pediatricians' surgeries (active surveillance). Obtained data were correlated with data available at SUKL (passive surveillance). The study data showed higher number of collected adverse reactions that number of adverse reactions reported to national program...
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Levels of specific antibodies against measles, in university hospital staff, during the 2018-2019 measles outbreak in Prague, CZ
Malinová, Jana ; Čelko, Alexander (advisor) ; Částková, Jitka (referee) ; Göpfertová, Dana (referee)
Levels of specific antibodies against measles, in university hospital staff, during the 2018-2019 measles outbreak in Prague, CZ. MUDr. Jana Malinová Between May 2018 and December 2019, during an epidemic measles outbreak in the Czech Republic, especially in Prague, a prospective serological study was conducted by staff at the Kralovske University Hospital, which focused on determining the measles seropositivity of the Kralovske University Hospital personal. During the study, a total of 2,782 university hospital employees, between the ages of 19-89 years, were examined. The aim of the study was to determine whether the measles seropositivity rate in health care staff was greater than 90 % and whether seropositivity was affected by any of the studied variables such as gender, age, natural vs. acquired immunity, overweight or obesity, smoking, and concomitant disease. Since childhood immunity, obtained either by infection or vaccination, was assumed, seropositivity persistence into adulthood was also evaluated. The results of the study confirmed that the seropositivity of medical personnel was greater than 90 % independently of how it was acquired. However, seropositivity was higher (98 %) in those who had natural immunity via a childhood measles infection. Although vaccination with at least one dose of the...
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Adverse reactions after childhood vaccination in the Czech Republic
Kocourková, Aneta ; Dáňová, Jana (advisor) ; Marešová, Vilma (referee) ; Částková, Jitka (referee)
1 ABSTRACT In the Czech Republic a complex study of adverse reactions after vaccination in children has not been presented yet. Even though reporting of serious adverse reactions to the State Institute for Drug Control (SUKL) is mandatory by law, it is seldom performed. Moreover, there is no analysis correlating adverse reactions that occurred at doctors` surgeries with actual reported adverse reactions to SUKL. The main focus of presented work was to analyze and map adverse reactions appearing after vaccinations from the children's vaccination schedule in the Czech Republic. The study was conducted in the form of retrospective-prospective questionnaires concentrating on adverse reactions, their occurrence, character, seriousness, duration and frequency. Furthermore, the questionnaires also focused on socio-demographic data such as gender, age, residency, parents' education, birth weight. Also, the refusal of the compulsory vaccination was assessed. Occurrence of adverse reactions after vaccination in the Czech Republic was analyzed by questionnaires in pediatricians' surgeries (active surveillance). Obtained data were correlated with data available at SUKL (passive surveillance). The study data showed higher number of collected adverse reactions that number of adverse reactions reported to national program...
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