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Hereditary Equine Regional Dermal Asthenia in horses used for hiporehabilitation
Zrůstová, Jana ; Sedláková, Vladimíra (advisor) ; Hofmanová, Barbora (referee)
This bachelor thesis is processed as a literary review, and its aim is to collect, study assessment of the current literature presented findings about disease Hereditary regional dermal asthenia in horses used for hiporehabilitation.
Hiporehabilitation is a very valuable form of treatment and helps people with physical and mental health problems. It is very important though that the horse, which is an irreplaceable part of rehabilitations and theraphies, was as healthy as possible.
Hereditary equine regional dermal asthenia (HERDA) is a novel genetic disease affecting mainly Paint horses, Appalloosas and Quarter horses, to whom one whole chapter was given. The last breed is the most affected of them all due to a high level of inbreeding especially in high valued top cutting horses. The main manifestations of HERDA are hyperelastic skin, skin lesions, pseudotumors, and hypermobility. It is a recessive disease caused by missense mutation of one base in PPIB gene located on the first chromosome (ECA1).
Because of the fact HERDA affects mainly Quarter horses, all stallions have to go trought a panel test which is compulsory since 2015. This test covers all genetic disorders of the breed which are PSSM, GBED, MH, HYPP and HERDA. The main causes of these diseases, heredity and clinical symptoms, are being described in this thesis as well.
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