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Autoimmune thyroiditis in children and the role of simultaneous Helicobacter pylori infection
Pomahačová, Renata ; Sýkora, Josef (advisor) ; Hníková, Olga (referee) ; Kalvachová, Božena (referee)
1. Summary The first aim of our study was to find out the present occurence of H. pylori infection in a group of children with juvenile lymphocytic thyroiditis (JLT) and to compare with the prevalence of this infection in a group of healthy children of the same age. The group of patients with JLT included 199 children (range 0-18 years). H. pylori infection was confirmed in 15 patients (7,5%) by a non-invasive diagnostic test of H. pylori antigen positivity in stools by the ELISA test using monoclonal antibodies (Amplified IDEIQA HpStAR ELISA, DakoCytomation, Glostrup, Denmark). This H.pylori positive group included 14 girls and 1 boy aged 11,2 ±2,3. 6 children had hypofunction of the thyroid gland, in 3 children was established the atrophic form of the thyroiditis with severe hypothyroidism with presence of myxoedema, the other children suffered from the hypertrophic form of the thyroiditis. 7 subjects underwent gastroscopy which confirmed chronic active gastritis. Only 3 children had gastrointestinal symptoms caused by H. pylori infection, the other children were asymptomatic. This finding confirms common information about asymptomatic development of H. pylori infection in children in 90% of cases. The control group included 1545 asymptomatic healthy children in range of 0-15 years of the same geographic...
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The impact of psychosocial and emotional stress on child growth and development
Benešovská, Stáňa ; Sedlak, Petr (advisor) ; Kalvachová, Božena (referee)
Chronic exposure to stress in humans causes a stress response in the body. Its task is to maintain homeostasis and protect the body from damage. Stress has been shown to adversely affect nervous and endocrine regulatory mechanisms. Closer attention is paid to the effect on the reproductive, thyroid and somatotropic axis. The aim of this work is to summarize the basic knowledge about the impact of psychosocial and emotional stress on the postnatal growth and development of the child and describe the related pathophysiological processes.
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The effect of vitamin D on the health of children and adolescents
Schönová, Markéta ; Kalvachová, Božena (advisor) ; Zíma, Zdeněk (referee)
The biologically active vitamin D metabolite is essential for the human body. And it is involved in the regulation of the function of most human cells. It is believed to affect up to 900 genes transcription. Thus, its insufficient amount may contribute to the pathogenesis of many diseases. It regulates calcium homeostasis, participates in bone development, and maintains optimal bone status. On the basis of the new knowledge of vitamin D, his out-of-bone effects are currently at the forefront. These relate to the immune system, metabolism, the nervous system, and the effect on the developing fetus. The aim of this work was to create a comprehensive overview of the effect of vitamin D on the young organism. And then, on the basis of questionnaire research, support or refute the hypothesis that children suffer from vitamin D deficiency in winter and spring. The secondary objective of the thesis is to create promotional material that contributes to increasing the interest of parents and older children in this issue and improving their awareness. Based on the knowledge of the effects of vitamin D, a questionnaire survey was conducted with eleven questions related to vitamin D. The research sample consisted of 134 children aged between three and fifteen who were divided into three groups by age. The results of...
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The impact of stress factors on child growth and development
Samešová, Daniela ; Sedlak, Petr (advisor) ; Kalvachová, Božena (referee)
Chronic exposure to stress negatively affects the prenatal and postnatal period of growth and development of humans. The major source of stress for the foetus during the prenatal period is the mother, while during the postnatal period stressors act directly on the individual. The aim of this work is to summarize the basic available knowledge about the psychosocial and emotional impact of stress on the growth and development of the child. Stress response mechanisms and their pathophysiological effects are observed in relation to the growth and development schemes during the prenatal period, childhood and adolescent.
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Autoimmune thyroiditis in children and the role of simultaneous Helicobacter pylori infection
Pomahačová, Renata ; Sýkora, Josef (advisor) ; Hníková, Olga (referee) ; Kalvachová, Božena (referee)
1. Summary The first aim of our study was to find out the present occurence of H. pylori infection in a group of children with juvenile lymphocytic thyroiditis (JLT) and to compare with the prevalence of this infection in a group of healthy children of the same age. The group of patients with JLT included 199 children (range 0-18 years). H. pylori infection was confirmed in 15 patients (7,5%) by a non-invasive diagnostic test of H. pylori antigen positivity in stools by the ELISA test using monoclonal antibodies (Amplified IDEIQA HpStAR ELISA, DakoCytomation, Glostrup, Denmark). This H.pylori positive group included 14 girls and 1 boy aged 11,2 ±2,3. 6 children had hypofunction of the thyroid gland, in 3 children was established the atrophic form of the thyroiditis with severe hypothyroidism with presence of myxoedema, the other children suffered from the hypertrophic form of the thyroiditis. 7 subjects underwent gastroscopy which confirmed chronic active gastritis. Only 3 children had gastrointestinal symptoms caused by H. pylori infection, the other children were asymptomatic. This finding confirms common information about asymptomatic development of H. pylori infection in children in 90% of cases. The control group included 1545 asymptomatic healthy children in range of 0-15 years of the same geographic...
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