National Repository of Grey Literature 22 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Wall shear stress and its role in progress of atherosclerosis
Chytilová, Eva ; Malík, Jan (advisor) ; Horký, Karel (referee) ; Piťha, Jan (referee)
Atherosclerosis is associated with systemic risk factors such as hypertension, hyperlipidemia, diabetes mellitus and smoking. Nonetheless, atherosclerosis is a focal disease, preferentially affecting predisposed areas. The main local hemodynamic factor is wall shear stress, the frictional force acting tangencially on the endothelial cell surface. The effect of wall shear stress depends on its magnitude and direction, as well as on the characteristic of vessel geometry and blood flow. Wall shear stress is an important determinant of endothelial function and phenotype. Previous research showed that arterial sites with chronically low WSS are more prone to the development of atherosclerotic plaques. Mostly, it is the case of outer wall of arterial bifurcations, where the stroma of vessel wall prevents arterio-constriction in response to low WSS. However, lower WSS was described also in straight arterial segments, such as carotid arteries, in the presence of atherosclerosis risk factors.
Examination methods of skin microcirculation in diabetes foot syndrome
Krčma, Michal ; Rušavý, Zdeněk (advisor) ; Filipovský, Jan (referee) ; Horký, Karel (referee) ; Prázný, Martin (referee)
Introduction: Since the mid 1980s, a lot of attention has been dedicated to the importance of microcirculation; a part of arterial bed including arterioles, precapillary sphincters, capillaries, venules and arteriovenous shunts. It is a structure of decisive importance for an organism; in its domain an exchange of blood gases and metabolic products takes place and it contributes to thermoregulation. Mediation of vasomotor reaction and vasoarterial reflex maintaining a stable hydrostatic pressure is also an important function. Microcirculation is for its dimensions (capillary diameter approx. 5 x 10-5 mm2, blood flow velocity around 0.4 mm.s-1) relatively difficult to access for more detailed examination, yet its impairments are very severe and dominate in many metabolic disorders. Microcirculation impairment is crucial in diabetes mellitus, where arteriovenous shunts open at the expense of nutritive bed due to a loss of sympathetic tone in peripheral circulation in diabetic neuropathy (Netten, Houben). Blood flow is therefore seemingly sufficient, but the affected tissue undergoes ischemia (warm ischemia). To what extent hyperinsulinemia contributes to this effect is not yet clearly known, one of the possible explanations may be a stimulation of sympathetic activity. Not a few studies are dealing with...
Contribution of New Immunosuppressants after Heart Transplantation
Skalická, Blanka ; Málek, Ivan (advisor) ; Horký, Karel (referee) ; Lischke, Robert (referee)
Background: Acute cellular rejection and graft vascular disease are major factors limiting the survival after orthotopic heart transplantation (OHTx). Tacrolimus could be more potent than cyclosporin A in therapy of recurrent acute rejection episodes in OHTx patients. Dyslipidemia is one of the risk factors involved in the development of graft vascular disease. Statins are common part of standard drug regimen after OHTx. On the other hand, they are potentially dangerous as they could interact with cyclosporin A. Study in healthy volunteers showed that tacrolimus should have no interactions with statins. Aim: In the first study we retrospectively assessed the effect of switching patients after OHTx with recurrent cellular rejection episodes from cyclosporin A to tacrolimus. In the second (prospective) study we evaluated the efficacy and safety of combined therapy with tacrolimus and atorvastatin in patients after OHTx with dyslipidemia. (...) Conclusions: Tacrolimus has a beneficial effect not only on recurrent acute rejection episodes in heart transplant recipients but it also decreases the incidence of future rejection episodes. In patients after OHTx with dyslipidemia switching to tacrolimus and atorvastatin could be a suitable therapeutic option, because this combination is safe and effective in...
Relationship of C-reactive protein and copper concentration as a laboratory markers of inflammation to the clinical and prognostic indicators in patients with chronic heart failure of ischemic etiology
Málek, Filip ; Špaček, Rudolf (advisor) ; Špinarová, Lenka (referee) ; Hradec, Jaromír (referee) ; Horký, Karel (referee)
In patients with chronic heart failure of ischemic etiology and systolic left ventricular dysfunction was evaluated significance of determination of concentrations of acute phase proteins and serum concentrations of copper. Showed statistically significant correlation between the concentration of C-reactive protein and parameters of cardiac function. Our work found a significant inverse relationship between CRP concentration and left ventricular ejection fraction and a significant positive correlation of CRP concentration on the degree of diastolic left ventricular dysfunction. It was also found statistically significant correlation between the concentration of acute phase proteins C-reactive protein, fibrinogen and serum concentrations of copper. It was also further demonstrated the relationship of serum concentrations of copper to the degree of cardiac insufficiency and significant correlation between serum copper concentration to the resting heart rate.
Design of flywheel of jaw crusher
Horký, Karel ; Kala, Pavel (referee) ; Škopán, Miroslav (advisor)
Diploma thesis deals with design of a flywheel and a belt pulley of single toggle jaw crusher DCJ 900x600. The first part is dedicated to overview of the methods for calculation of a size of flywheels for working machines. The second part is focused on calculation of a size of the flywheel. The third part treats the constructional design of the flywheel. In the last two parts there is elaborated analysis of a changing size of the flywheel depended on increasing the working rotation speed and change of coefficient .
Aldosterone synthase in arterial hypertension and possible influence of its genenetic polymorphism on left ventricular hypertrophy
Heller, Samuel ; Horký, Karel (advisor) ; Málková, Jana (referee) ; Widimský, Jiří (referee)
Part I. The aldosterone synthase gene (CYP11B2) polymorphism T-344C in blood pressure and left ventricular hypertrophy. BACKGROUND: Aldosterone is a key cardovascular hormone, it significantly influences volume, pressure and electrolyte balance. Aldosterone plays an important role in development of left ventricular (LV) hypertrophy and myocardial fibrosis. The aldosterone synthase gene (CYP11B2) is an important candidate gene region in essential hypertension. DESIGN AND METHODS: We assessed the influence of the T-344C polymorphism of aldosterone synthase - the rate-limiting enzyme in aldosterone biosynthesis - on the structure of the left ventricle in young normotensive men. The population included 113 normotensive mid-European Caucasian men aged 18-40 years (mean 27 +/- 5 years). We also studied the association of -344T/C polymorphism of the CYP11B2 gene with the presence and severity of hypertension in 369 individuals, of whom 213 were hypertensive patients (139 controlled hypertensive, 74 resistant hypertensive) and 156 were healthy normotensive subjects. The genotype was assessed using polymerase chain reaction with subsequent cleavage with restriction enzyme HAEIII (restriction fragment length polymorphism method) and visualization with ethidium bromide. Plasma renin activity (PRA) and plasma...
Additional working equipment and tools for machines for excavators
Horký, Karel ; Pokorný, Přemysl (referee) ; Škopán, Miroslav (advisor)
This bachelor thesis is focused on research of hydraulic demolition hammers and hydraulic demolition shares that are manufactured and used to demolish the buildings nowadays. There is written down a research of types of equipment for an application on different types of excavators in both cases. In this thesis there is a comparison of this equipment also included. Comparison is written down to the tables and drawn to the graphs. Moreover there is included a survey of additional equipment for crushing and separating a structural rubble.
Relationship of C-reactive protein and copper concentration as a laboratory markers of inflammation to the clinical and prognostic indicators in patients with chronic heart failure of ischemic etiology
Málek, Filip ; Špaček, Rudolf (advisor) ; Špinarová, Lenka (referee) ; Hradec, Jaromír (referee) ; Horký, Karel (referee)
In patients with chronic heart failure of ischemic etiology and systolic left ventricular dysfunction was evaluated significance of determination of concentrations of acute phase proteins and serum concentrations of copper. Showed statistically significant correlation between the concentration of C-reactive protein and parameters of cardiac function. Our work found a significant inverse relationship between CRP concentration and left ventricular ejection fraction and a significant positive correlation of CRP concentration on the degree of diastolic left ventricular dysfunction. It was also found statistically significant correlation between the concentration of acute phase proteins C-reactive protein, fibrinogen and serum concentrations of copper. It was also further demonstrated the relationship of serum concentrations of copper to the degree of cardiac insufficiency and significant correlation between serum copper concentration to the resting heart rate.
Comparison of QT dispersion and heart rate turbulence
Havránek, Štěpán ; Kittnar, Otomar (advisor) ; Horký, Karel (referee) ; Slavíková, Jana (referee)
Introduction: Both QT dispersion (QTD) and heart rate turbulence (HRT) were studied and tested like potential noninvasive markers for risk stratification. Aims: Compare QTD between different groups of patients with expected different mechanism of developing changes in QTD. Investigate if HRT is present following ventricular train drives and depends on left ventricular dysfunction. Test the hypothesis that QTD and HRT parameters assessed during programmed ventricular stimulation correlated to each other and there is association with iducibility of ventricular arrhythmia. Methods: We analysed body surface potential mapping (BSPM) recordings and vectorcardiographic T-loop parameters (T-loop width - Tw and T-loop amplitude - Ta) in 37 healthy women (20 - 36 yrs) in the 36th to 40th week of physiological pregnancy and 2 to 6 days after delivery. Control group contained 18 healthy women. Then we analysed BSPM recordings from 27 psychiatric outpatients treated with prophylactic doses of dosulepin (20 women, 44 ± 13 yrs) and compared to those obtained from 37 healthy volunteers. From these recordings the QTD was evaluated. This parameter was estimated using both BSPM recordings and 12 lead standard ECG. Acquired data were statistically correlated with Tw or Ta and dosulepin plasma levels, respectively. Distribution...
Allograft coronary artery disease
Kocík, Miroslav ; Málek, Ivan (advisor) ; Horký, Karel (referee) ; Hejnal, Jaroslav (referee)
We have proved high incidence of early detected TxCAD in OHTx recipients' population. Neither any of immunologic nor nonimmunologic factors tested in our study was found to represent a risk factor for early detected TxCAD development except of donor age and recipient's BMI. Despite proving survival to be worse in recipients suffering from early detected TxCAD in compare to the rest of OHTx recipients, we have failed to demonstrate, that early detected TxCAD is an independent risk factor for OHTx recipients negative clinical outcome. Similarly despite demonstration, that serious cardiac events are more frequent in subgroup of patients with early detected TxCAD, we have failed to prove early detected TxCAD to represent an independent risk factor for its occurrence.

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