National Repository of Grey Literature 253 records found  beginprevious231 - 240nextend  jump to record: Search took 0.01 seconds. 
Azaphthalocyanines as new structural group of fluorescence quencher.
Kopecký, Kamil ; Doležal, Martin (advisor) ; Lang, Kamil (referee) ; Pour, Milan (referee)
1 SUMMARY This dissertation thesis deals with searching of structurally new non-fluorescent quenchers of fluorescence, which may be used for preparation of molecular probes. These potential quenchers are derived from asymmetrically substituted alkylaminoderivatives of tetrapyrazinoporphyrazines - azaphthalocyanines. As the part of this work is preparation of precursors - 5,6-disubstituted pyrazine-2,3-dicarbonitriles. They are starting material for the preparation of final substances - tetrapyrazinoporphyrazines bearing different functional moieties. In total were prepared: 14 intermediates (3 of them have been described in our department) 13 final tetrapyrazinoporphyrazines (1 of them has been described in our department) 1 modified solid phase suitable for synthesis of marked oligonucleotides 2 by-products 23 undescribed compounds were prepared. Synthesis of 4 substances was not successful. Final products were tested for their singlet oxygen quantum yields, stability in solutions used for synthesis of oligonucleotides and subsequently ability of quenching of commercially available fluorofor Cy5® . This ability was compared with commercially available quencher Black Hole Quencher-2® . As a part of this work is confirmation of distribution of congeners arising during the statistical tetramerization of...
Pregnancy and profession of a nurse
Rusnáková, Marcela ; Tomová, Šárka (advisor) ; Doležal, Martin (referee)
The thesis discusses tbe attitude of nurses and women, without medical education, to pregnancy and childbirths on tbe bases of questionnaires which were distributed to women who were already pregnant or women who are nowadays pregnant. The thesis is divided into two parts - the theoretical and tbe empirical one. Tbe theoretical part re1ates to pregnancy and its physiological process, eating during pregnancy, prenamI care and possibilities of giving birth in the Czech Republic. Trus part is also about the nurse profession and above aH it is about risks taking at work. Tbe second empirical part relates to analysis of questionnaires results. The fmal assessment of the thesis includes appendices. Powered by TCPDF (www.tcpdf.org)
Derivatives of pyrazine as potential antituberculars (preparation and study of biological properties)
Janďourek, Ondřej ; Doležal, Martin (advisor) ; Farsa, Oldřich (referee) ; Musílek, Kamil (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical chemistry and Pharmaceutical analysis Candidate Mgr. Ondřej Janďourek Supervisor Prof. PharmDr. Martin Doležal, Ph.D. Consultant PharmDr. Jan Zitko, Ph.D. Title of Doctoral Thesis Derivatives of pyrazine as potential antituberculars (preparation and study of biological properties) This work is focused on pyrazine derivatives with the structural relationship to pyrazinamide (PZA) and with the potential antitubercular effect. In the introduction, there are summarized theoretical findings about tuberculosis (TBC), its epidemiology and primarily the development of resistance to current pharmacotherapy. Brief overview of known antituberculars, novel compounds and auspicious molecules in clinical trials is outlined. PZA, which is counted among the first line antitubercular agents, is widely described due to its cardinal role in this thesis. PZA possible mechanisms of action are described together with its pharmacological profile. Finally, brief summary of already prepared derivatives of PZA is stated. Practical part of this thesis is focused on synthesis of three starting compounds (5-chloro-6-methylpyrazine-2,3-dicarbonitrile; 3-chloropyrazine-2-carboxamide; N-benzyl-3-chloropyrazine-2-carboxamide) that were...
Derivatives of pyrazinecarboxylic acid as potential antituberculotics (synthesis and biological evaluation)
Vaňásková, Barbora ; Doležal, Martin (advisor) ; Zimčík, Petr (referee) ; Malík, Ivan (referee)
Charles University in Prague, Faculty of Pharmacy v Hradci Králové Department: Department of Pharmaceutical Chemistry and Drug Control Candidate: Mgr. Barbora Vaňásková Supervisor: Prof. PharmDr. Martin Doležal, Ph.D. Title of Doctoral Thesis: Derivatives of pyrazinecarboxylic acid as potential antituberculotics (synthesis and biological evaluation) This doctoral thesis deals with searching for potential antituberculotic drugs derived from pyrazinecarboxylic acid. Thesis contains theoretical part, in which problematics of tuberculosis, factors hindering the effectiveness of treatment (development of resistance and HIV coinfection) and current therapeutic practice are outlined. An individual chapter is devoted to the composition of the mycobacterial cell wall. A brief overview of first-line and second-line antituberculars as well as drugs newly introduced into the clinical practice and promising derivatives in various phases of preclinical and clinical trials is further stated. Special attention is dedicated to pyrazinamide, current theories dealing with mechanism of action of this first-line antituberculotic drug and to ribosomal protein S1, a specific target of pyrazinecarboxylic acid. A summary of pyrazinamide derivatives with antimycobacterial activity published since 2011 is listed for...

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