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Národní úložiště šedé literatury Nalezeno 2 záznamů.  Hledání trvalo 0.01 vteřin. 
Graph Neural Networks in Epilepsy Surgery
 Hrtonová, Valentina ; Filipenská, Marina ; Klimeš, Petr
Epilepsy surgery presents a viable treatment option for patients with drug-resistant epilepsy, necessitating precise localization of the epileptogenic zone (EZ) for optimal outcomes. As the limitations of currently used localization methods lead to a seizure-free postsurgical outcome only in about 60% of cases, this study introduces a novel approach to EZ localization by leveraging Graph Neural Networks (GNNs) for the analysis of interictal stereoelectroencephalography (SEEG) data. A GraphSAGE-based model for identifying resected seizure-onset zone (SOZ) electrode contacts was applied to a clinical dataset comprising 17 patients from two institutions. This study uniquely focuses on the use of interictal SEEG recordings, aiming to streamline the presurgical monitoring process and minimize risks and costs associated with prolonged SEEG monitoring. Through this innovative approach, the GNN model demonstrated promising results, achieving an Area Under the Receiver Operating Characteristic (AUROC) score of 0.830 and an Area Under the Precision-Recall Curve (AUPRC) of 0.432. These outcomes along with the potential of GNNs in leveraging the patient-specific electrode placement highlight their potential in enhancing the accuracy of EZ localization in drug-resistant epilepsy patients.
Úplný záznam
Graph Neural Networks in Epilepsy Surgery
 Hrtoňová, Valentina ; MSc, Daniel Uher, (oponent) ; Filipenská, Marina (vedoucí práce)
Successful epilepsy surgery relies on precise localization of the epileptogenic zone (EZ), yet only about 60% of patients become seizure-free post-surgery often due to inaccurate EZ identification. This thesis presents a novel method for EZ localization using Graph Neural Networks (GNNs) to analyze interictal biomarkers, specifically interictal spikes and relative entropy. The GNN models were used to localize resected seizure-onset zone electrode contacts based on interictal stereoelectroencephalography data, validated on a clinical dataset of 37 patients from two institutions. The best-performing GNN model - Graph Attention Network - scored a median Area Under the Receiver Operating Characteristic (AUROC) of 0.971 and a median Area Under the Precision-Recall Curve (AUPRC) of 0.525 across a cohort of 19 patients with a good surgical outcome, significantly outperforming a benchmark model based on spike rates (Wilcoxon Signed Rank test, p
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