Národní úložiště šedé literatury Nalezeno 60 záznamů.  1 - 10dalšíkonec  přejít na záznam: Hledání trvalo 0.02 vteřin. 
Bohl-Marek decomposition applied to a class of biochemical networks with conservation properties
Papáček, Štěpán ; Matonoha, Ctirad ; Duintjer Tebbens, Jurjen
This study presents an application of one special technique, further called as Bohl-Marek decomposition, related to the mathematical modeling of biochemical networks with mass conservation properties. We continue in direction of papers devoted to inverse problems of parameter estimation for mathematical models describing the drug-induced enzyme production networks [3]. However, being aware of the complexity of general physiologically based pharmacokinetic (PBPK) models, here we focus on the case of enzyme-catalyzed reactions with a substrate transport chain [5]. Although our ultimate goal is to develop a reliable method for fitting the model parameters to given experimental data, here we study certain numerical issues within the framework of optimal experimental design [6]. Before starting an experiment on a real biochemical network, we formulate an optimization problem aiming to maximize the information content of the corresponding experiment. For the above-sketched optimization problem, the computational costs related to the two formulations of the same biochemical network, being (i) the classical formulation x˙(t) = Ax(t) + b(t) and (ii) the 'quasi-linear' Bohl-Marek formulation x˙M(t) = M(x(t)) xM(t), can be determined and compared.
TESTING THE METHOD OF MULTIPLE SCALES AND THE AVERAGING PRINCIPLE FOR MODEL PARAMETER ESTIMATION OF QUASIPERIODIC TWO TIME-SCALE MODELS
Papáček, Štěpán ; Matonoha, Ctirad
Some dynamical systems are characterized by more than one timescale, e.g. two well separated time-scales are typical for quasiperiodic systems. The aim of this paper is to show how singular perturbation methods based on the slow-fast decomposition can serve for an enhanced parameter estimation when the slowly changing features are rigorously treated. Although the ultimate goal is to reduce the standard error for the estimated parameters, here we test two methods for numerical approximations of the solution of associated forward problem: (i) the multiple time-scales method, and (ii) the method of averaging. On a case study, being an under-damped harmonic oscillator containing two state variables and two parameters, the method of averaging gives well (theoretically predicted) results, while the use of multiple time-scales method is not suitable for our purposes.
Mathematics and Optimal control theory meet Pharmacy: Towards application of special techniques in modeling, control and optimization of biochemical networks
Papáček, Štěpán ; Matonoha, Ctirad ; Duintjer Tebbens, Jurjen
Similarly to other scienti c domains, the expenses related to in silico modeling in pharmacology need not be extensively apologized. Vis a vis both in vitro and in vivo experiments, physiologically-based pharmacokinetic (PBPK) and pharmacodynamic models represent an important tool for the assessment of drug safety before its approval, as well as a viable option in designing dosing regimens. In this contribution, some special techniques related to the mathematical modeling, control and optimization of biochemical networks are presented on a paradigmatic example of enzyme kinetics.
Hybrid Methods for Nonlinear Least Squares Problems
Lukšan, Ladislav ; Matonoha, Ctirad ; Vlček, Jan
This contribution contains a description and analysis of effective methods for minimization of the nonlinear least squares function F(x) = (1=2)fT (x)f(x), where x ∈ Rn and f ∈ Rm, together with extensive computational tests and comparisons of the introduced methods. All hybrid methods are described in detail and their global convergence is proved in a unified way. Some proofs concerning trust region methods, which are difficult to find in the literature, are also added. In particular, the report contains an analysis of a new simple hybrid method with Jacobian corrections (Section 8) and an investigation of the simple hybrid method for sparse least squares problems proposed previously in [33] (Section 14).
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On the Optimal Initial Conditions for an Inverse Problem of Model Parameter Estimation - a Complementarity Principle
Matonoha, Ctirad ; Papáček, Š.
This contribution represents an extension of our earlier studies on the paradigmatic example of the inverse problem of the diffusion parameter estimation from spatio-temporal measurements of fluorescent particle concentration, see [6, 1, 3, 4, 5]. More precisely, we continue to look for an optimal bleaching pattern used in FRAP (Fluorescence Recovery After Photobleaching), being the initial condition of the Fickian diffusion equation maximizing a sensitivity measure. As follows, we define an optimization problem and we show the special feature (so-called complementarity principle) of the optimal binary-valued initial conditions.
Problems for Nonlinear Least Squares and Nonlinear Equations
Lukšan, Ladislav ; Matonoha, Ctirad ; Vlček, Jan
This report contains a description of subroutines which can be used for testing large-scale optimization codes. These subroutines can easily be obtained from the web page http://www.cs.cas.cz/~luksan/test.html. Furthermore, all test problems contained in these subroutines are presented in the analytic form.
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Sparse Test Problems for Nonlinear Least Squares
Lukšan, Ladislav ; Matonoha, Ctirad ; Vlček, Jan
This report contains a description of subroutines which can be used for testing large-scale optimization codes. These subroutines can easily be obtained from the web page http://www.cs.cas.cz/~luksan/test.html. Furthermore, all test problems contained in these subroutines are presented in the analytic form.
Plný tet: V1258-18 - Stáhnout plný textPDF
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Mocnění intervalových matic
Říha, David ; Hartman, David (vedoucí práce) ; Matonoha, Ctirad (oponent)
Cílem práce je prozkoumat způsoby jak spočítat intervalovou obálku pro mocninu intervalové matice, najít speciální případy, kdy je mocnění jednodušší než v obecném případě a tyto vyzkoumané způsoby implementovat pro program MATLAB. V práci budou představeny dva algoritmy pro výpočet obálky mocniny obecné intervalové matice. Jeden využívá spektrální rozklad, tedy rozklad založený na vlastních číslech a vlastních vektorech a druhý je založen na známém postupu binárního umocňování. Speciální případy zahrnují například nezáporné intervalové matice, nebo třetí mocninu diagonálně intervalových matic. Pro vyzkoumané metody je vysvětlena teorie, na které jsou postaveny a samotné metody jsou popsány jak slovně, tak kódem. Na konci práce je provedeno testování kvality výsledných intervalových obálek a časové náročnosti výpočtu.

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