National Repository of Grey Literature 60 records found  beginprevious51 - 60  jump to record: Search took 0.02 seconds. 
The effect of tick saliva on the interactions between \kur{Borrelia afzelii} spirochetes and murine dendritic cells.
SLÁMOVÁ, Martina
Interaction between mouse dendritic cells (DCs) and Borrelia afzelii spichochetes was studied on three different levels: phagocytosis of borrelia by DCs, production of cytokines by borrelia-activated DCs and the ablilty of DCs to activate CD4+ T cells. The effect of Ixodes ricinus saliva on each of these levels was examined. Tick saliva was shown to decrease the number of phagocosing DCs. The ability of borrelia-activated DCs to induce both proliferation and IL-2 production in specific CD4+ T cells was significantly reduced by tick saliva. And surprisingly, we have shown an inhibitory effect of I. ricinus saliva on the production of both Th1 (IL-6 and TNF-{$\alpha$}) and Th2 (IL-10) cytokines. Our data reveal a complex inhibitory effect of tick saliva on DC function.

National Repository of Grey Literature : 60 records found   beginprevious51 - 60  jump to record:
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